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UnknownIdentification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study.
Not available
S-EPMC3595425 | biostudies-literature
TranscriptomicsGene expression profiles of mono- and biallelic CEBPA mutations in cytogenetically normal AML
Purpose: CEBPA mutations are found as either biallelic (biCEBPA) or monoallelic (moCEBPA). We set out to explore whether the kind of CEBPA mutation is of prognostic relevance in cytogenetically normal AML (CN-AML). Patients and Methods: 467 homogeneously treated CN-AML patients were subdivided into ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-15210 | biostudies-arrayexpress
TranscriptomicsExpression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20
In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is no...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-25571 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27513 | biostudies-arrayexpress
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA)
The t(10;11) p (13;q14) translocation, giving rise to CALM-AF10, is a recurring chromosomal translocation observed in several types of acute leukemias as well as in lymphoma. We have previously demonstrated that the expression of the human CALM/AF10 fusion gene in murine bone marrow stem and progeni...
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27512 | biostudies-arrayexpress
TranscriptomicsPrognostic gene signature for AML
Acute myeloid leukemia (AML) is a heterogeneous disease in respect of molecular aberrations and prognosis. We used gene expression profiling of 562 patients treated in the German AMLCG 1999 trial to develop a gene signature that predicts survival in AML. Analysis of 562 samples (140 HGU-133plus2; 42...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-37642 | biostudies-arrayexpress
TranscriptomicsAn eight-gene expression signature for the prediction of survival and time to treatment in chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a common and heterogeneous disease. An accurate prediction of outcome is highly relevant for the development of personalized treatment strategies. Microarray technology was shown to be a useful tool for the development of prognostic gene expression scores. Howev...
ORGANISM(S): Homo sapiens 
2011-10-13 | E-GEOD-22762 | biostudies-arrayexpress
Genomicsena-DATASET-VUMC-CCA-12-10-2016-16:43:39:044-188 - samples
Background: In follicular lymphoma (FL), studies addressing the prognostic value of microenvironment-related immunohistochemical (IHC) markers and tumor cell-related genetic markers have yielded conflicting results, precluding implementation in practice. Therefore, the Lunenburg Lymphoma Biomarker C...
EGAD00001002738 | EGA
GenomicsPrognostic relevance of microenvironmental factors CD163 and CD8 combined with EZH2 and chromosome 18 gain in a validation cohort of follicular lymphoma patients of the Lunenburg Lymphoma Biomarker Consortium
Background: In follicular lymphoma (FL), studies addressing the prognostic value of microenvironment-related immunohistochemical (IHC) markers and tumor cell-related genetic markers have yielded conflicting results, precluding implementation in practice. Therefore, the Lunenburg Lymphoma Biomarker C...
EGAS00001002049 | EGA
UnknownDifferential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study.
Not available
S-EPMC8905706 | biostudies-literature
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