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TranscriptomicsHDAC3 modulates enhancer activity to regulate terminal B cell differentiation
B220+GL7+ (GC) and B220+GL7- (non-GC) B cells were sorted from SRBC-immunized mice deficient for Hdac3 and wild type controls. RNA-sequencing revealed an upregulation of critical regulators of B cell differentiation in Hdac3-deleted animals. 10 days post-immunization with SRBCs, GC and non-GC B cell...
ORGANISM(S): Mus musculus 
2016-09-02 | E-GEOD-77113 | biostudies-arrayexpress
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [RNA-seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [RNA-seq]
PRJNA673230 | ENA
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [MNAse-Seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [MNAse-Seq]
PRJNA911309 | ENA
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [ATAC-seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [ATAC-seq]
PRJNA673249 | ENA
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [PRO-seq]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [PRO-seq]
PRJNA673231 | ENA
GenomicsHuman SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [CUT&RUN]
Human SMARCA5 Is Continuously Required to Maintain Nucleosome Spacing [CUT&RUN]
PRJNA673248 | ENA
TranscriptomicsHigh Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML
Bromodomain and extra-terminal domain (BET) family inhibitors offer a new approach to treating hematological malignancies. We used precision nuclear run-on transcription sequencing (PRO-seq) to create high-resolution maps of active RNA polymerases across the genome in t(8;21) acute myeloid leukemia ...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-83660 | biostudies-arrayexpress
ProteomicsDeletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity
ORGANISM(S): Mus musculus (Mouse) 
2020-01-13 | PXD015738 | Pride
Hdac3 
UnknownDeletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.
Not available
S-EPMC6876593 | biostudies-literature
TranscriptomicsHDAC3 requirement for the inflammatory gene expression program in macrophages [gene expression]
Pan-Hdac inhibitors (HDACi) are endowed with a potent anti-inflammatory activity, but the relative role of each of the eleven Hdac proteins sensitive to HDACi to the inflammatory gene expression program is unknown. Using an integrated genomic approach we found that Hdac3-deficient macrophages are un...
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-33162 | biostudies-arrayexpress
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