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MetabolomicsMetabolic programming and functional remodeling by a c-di-GMP-centric hierarchy in aerobic granular sludge

This study systematically elucidates the hierarchical signaling regulatory network in aerobic granular sludge (AGS) by integrating dynamic analysis of quorum sensing signal molecules, microbial community structure profiling, and metabolomic characterization. The research reveals that c-di-GMP fun...

2025-12-10 | MTBLS13486 | MetaboLights
Genomicssocial hierarchy
social hierarchy Raw sequence reads
PRJNA1108947 | ENA
TranscriptomicsA Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation, however, instances of CD133- cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a s...
ORGANISM(S): Homo sapiens 
2010-04-21 | E-GEOD-19612 | biostudies-arrayexpress
GenomicsSpreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations
Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichm...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-36905 | biostudies-arrayexpress
ProteomicsSocial Hierarchy alters Drug Reward and the Protein Phosphorylation in the Nucleus Accumbens
Protein phosphorylation, a type of post-translational modification (PTM), has been identified in the addiction process. However, its role in social hierarchy remains poorly understood. In this study, we used the tube test to classify rats as dominants or subordinates. In the CPP paradigm, subordinat...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-04-09 | PXD062735 | Pride
Lc-msms Rat Nucleus accumbens 
GenomicsThe cellular hierarchy of acute myeloid leukemia informs personalized treatment
The cellular hierarchy of acute myeloid leukemia informs personalized treatment
PRJNA1137956 | ENA
TranscriptomicsDrosophila Sex Hierarchy Regulated Gene Expression in 48 hour APF Pupae
Drosophila melanogaster undergoes a complete metamorphosis, during which time the larval male and female forms transition into sexually dimorphic, reproductive adult forms. To understand this complex morphogenetic process at a molecular-genetic level, we performed whole genome microarray analyses. ...
ORGANISM(S): Drosophila melanogaster 
2009-02-10 | E-GEOD-11311 | biostudies-arrayexpress
GenomicsDistinct prefrontal projections oppositely orchestrate social competition and hierarchy
Distinct prefrontal projections oppositely orchestrate social competition and hierarchy
PRJNA918420 | ENA
TranscriptomicsWhole genome microarray analysis of the Drosophila morphogenetic process
This SuperSeries is composed of the following subset Series: GSE11311: Drosophila Sex Hierarchy Regulated Gene Expression in 48 hour APF Pupae GSE11313: Drosophila Gene Expression During Metamorphosis in Wild Type and Germline Minus Pupae Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2009-02-10 | E-GEOD-11316 | biostudies-arrayexpress
GenomicsA Hierarchy of H3K4me3 and H3K27me3 Acquisition in Spatial Gene Regulation in Xenopus Embryos
Epigenetic mechanisms set apart the active and inactive regions in the genome of multicellular organisms to produce distinct cell fates during embryogenesis. Here, we report on the epigenetic and transcriptome genome-wide maps of gastrula-stage Xenopus tropicalis embryos using massive parallel seque...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2009-09-15 | E-GEOD-14025 | biostudies-arrayexpress
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