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TranscriptomicsMicroarray data obtained from control, cbtRNAi and cbtOE flies
Microarray data obtained from control, cbtRNAi (cabut RNAi), and cbtOE (cabut overexpression) flies. From each strain, fly heads at two different time points during the day–night cycle (ZT3 and ZT153) were collected. Fly heads were collected and RNA was extracted. RNA was then used to prepare a pr...
ORGANISM(S): Drosophila melanogaster 
2015-05-08 | E-GEOD-67865 | biostudies-arrayexpress
Transcriptomics3' RNA-seq of flies over-expressing cabut protein or RNAi against cabut mRNA
CbtOE (Tim-gal4; UAS-cbtFLAG), Tim-gal4 (control for CbtOE), cbtRNAi (Tim-gal4-UAS-Dcr2-UAS-cbtIR-cbtE1) and Tim-gal4;UAS-Dcr2 (control for CbtRNAi) flies. Flies were entrained in LD (light: dark) condition for 3-4 days and harvested at six time points: ZT3, ZT7, ZT11, ZT15, ZT19, ZT23 Fly heads we...
ORGANISM(S): Drosophila melanogaster 
2015-05-08 | E-GEOD-67590 | biostudies-arrayexpress
Transcriptomics3' RNA-seq of fly expressing cabut RNAi after exposure to different levels of sucrose
Control (+/cbtE1-UAS-cbt RNAi) or cabut RNAi flies (Tim-gal4, UAS-cbt RNAi) were starved for 16 hours and then exposed to food containing different concentrations of sucrose: 0, 25, 50 and 100 % for 18 hours. Fly heads were collected, RNA was extracted and RNA-seq libraries were prepared as prev...
ORGANISM(S): Drosophila melanogaster 
2015-05-08 | E-GEOD-58854 | biostudies-arrayexpress
GenomicsDm-aKG treated Intestinal stem cells NEBNext Enzymatic 5hmC-seq (E5hmC-seq) sequencing and data processing
To analyze aKG-induced Tet mediated changes to DNA hydroxymethylation in intestinal stem cell
ORGANISM(S): Mus musculus 
2025-05-07 | E-MTAB-15115 | biostudies-arrayexpress
TranscriptomicsWhole-genome oxidative bisulfite sequencing and data processing of mouse intestinal stem cells with old and young mitochondria
The intent of the study was to profile the methylome and hydroxymethylome in intestinal stem cells with young mitochondria or old old mitochdondria, to ascertain the potential role of mitochondrial age specific influence on epigenetic regulation of ISCs.
ORGANISM(S): Mus musculus 
2025-05-07 | E-MTAB-15119 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Dm-aKG treated intestinal stem cells (ISCs) and controls
The object of this study was to investigate how aKG impacts mouse intestinal stem cell (ISCs) function and fate decisions in vivo. Mice were treated for 7 days with twice daily aKG IP injections after which ISCs were FACS sorted and transcriptomically anayzled. This revealed a striking set of secret...
ORGANISM(S): Mus musculus 
2025-05-02 | E-MTAB-15105 | biostudies-arrayexpress
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