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MetabolomicsAn Airway Organoid-Based Screen Identifies a Role for the HIF1α-Glycolysis Axis in SARS-CoV-2 Infection
Not available
ORGANISM(S): Homo sapiens 
ST001921 | MetabolomicsWorkbench
TranscriptomicsPAR-CLIP of RBM4 and HIF-2a
To identify which mRNAs bind to RBM4/HIF-2a Two PAR-CLIPs were performed: One of an RBM4 immunoprecipitation, and the other of a HIF-2a immunoprecipitation and excising the associated RBM4 band.
ORGANISM(S): Homo sapiens 
2012-05-06 | E-GEOD-36247 | biostudies-arrayexpress
GenomicsHIF-2a in the development of NASH
HIF-2a in the development of NASH
PRJNA937720 | ENA
GenomicsCancer associated HIF-2a governs trunk neural crest stemness
Cancer associated HIF-2a governs trunk neural crest stemness
PRJNA589281 | ENA
GenomicsHeterogeneous effects of massive hypoxia pathway activation in kidney cancer
General activation of hypoxia-inducible factor (HIF) pathways is classically associated with adverse prognosis in cancer and has been proposed to contribute to oncogenic drive. In clear cell renal carcinoma (CCRC) HIF pathways are upregulated by inactivation of the von-Hippel-Lindau tumour suppresso...
ORGANISM(S): Homo sapiens 
2015-07-10 | E-GEOD-67237 | biostudies-arrayexpress
GenomicsChIP-seq analysis of HIF-1a and HIF-2a binding in hypoxic cancer cell lines
ChIP-seq analysis of HIF-1a and HIF-2a binding in hypoxic cancer cell lines
PRJNA823676 | ENA
TranscriptomicsIdentification of hypoxia regulated HIF-1A and HIF-2A specific target genes in Glioblastoma
HIF-1A and HIF-2A regulate both overlapping and unique target genes in response to hypoxia. In this dataset, we identify specific HIF-1A and HIF-2A target genes in glioblastoma cells. 12 samples were analysed comprising 4 experimental conditions (normoxia scr, hypoxia scr, hypoxia siHIF1, hypoxia si...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-27523 | biostudies-arrayexpress
ProteomicsHIF-2a drives hepatic Kupffer cell death and liver inflammation in nonalcoholic steatohepatitis
Proinflammatory activation of hepatic macrophages plays a key role in the development of nonalcoholic steatohepatitis (NASH). This involves increased embryonic hepatic Kupffer cell (KC) death, facilitating the placement of KCs with bone marrow-derived recruited hepatic macrophages (RHMs) that highly...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040457 | Pride
Nonalcoholic fatty liver disease (nafld) Macrophage Obesity Proinflammatory macrophage activation Nonalcoholic steatohepatitis (nash) Inflammation/metaflammation Hif-2a Kupffer cell death Hypoxia 
GenomicsHIF-1a and HIF-2a differently regulate tumour development, metabolism and inflammation of clear cell renal cell carcinoma in mice
HIF-1a and HIF-2a differently regulate tumour development, metabolism and inflammation of clear cell renal cell carcinoma in mice
PRJNA634318 | ENA
TranscriptomicsChIP-chip from human liver cancer cells with HIF-2a
The transcription factor HIF-2a play an important role in the tumor progress, the aim is to explore the target genes of HIF-2a in liver cancer cell line. Chromatin immunoprecipitation (ChIP) of HIF-2a together with chromatin profiling by ChIP-on-chip analysis demonstrated that HIF-2a directly activ...
ORGANISM(S): Homo sapiens 
2012-04-11 | E-GEOD-37167 | biostudies-arrayexpress
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