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MetabolomicsMulti-Omic Analysis and Platelet Function Distinguish Treatment Responses to Hydroxytyrosol in Cardiovascular Risk
Many polyphenols have been recognized for their antioxidant and health benefits. The present study attempted, for the first time, to determine the effects of daily oral intake of β-cyclodextrin-encapsulated hydroxytyrosol (HT) on plasma platelet reactivity and proteomic and metabolomic profiles of p...
2025-06-30 | MTBLS12336 | MetaboLights
TranscriptomicsPlatelet microRNA-mRNA Co-Expression Profiles Correlate with Platelet Reactivity
MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that...
ORGANISM(S): Homo sapiens 
2011-09-26 | E-GEOD-27917 | biostudies-arrayexpress
TranscriptomicsNew molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach [Affymetrix]
Platelet reactivity (PR) in cardiovascular (CV) patients is variable between individuals and modulates clinical outcome. However, the determinants of platelet reactivity are largely unknown. Integration of data derived from high-throughput omics technologies may yield novel insights into the molecul...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-66426 | biostudies-arrayexpress
Proteomics,Multiomicsplatelet hyperreactivity project
The aim of this study is to identify candidate genes modulating platelet reactivity in aspirin-treated cardiovascular patients using an integrative network-based approach. Platelet reactivity was assessed in 110 cardiovascular patients treated with aspirin 100mg/d by aggregometry using several agoni...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-14 | MSV000083572 | MassIVE
Proteomicsplatelet hyperreactivity project
The aim of this study is to identify candidate genes modulating platelet reactivity in aspirin-treated cardiovascular patients using an integrative network-based approach. Platelet reactivity was assessed in 110 cardiovascular patients treated with aspirin 100mg/d by aggregometry using several agoni...
ORGANISM(S): Homo sapiens (Human) 
2016-02-22 | PXD001861 | Pride
Releasate Secretory granules Cardiovascular patients Aspirin Network biology High platelet reactivity Platelets 
TranscriptomicsPlatelet microRNA expression profiles of acute coronary syndrome patients with high and low platelet reactivity
To explore the diverse platelet microRNA (miRNA) expression between high platelet reactivity (HPR) and low platelet reactivity (LPR) patients with acute coronary syndromes (ACS), we enrolled a cohort of ACS patients and performed miRNA expression profiling of platelets from four HPR and four LPR pat...
ORGANISM(S): Homo sapiens 
2014-07-17 | E-GEOD-59488 | biostudies-arrayexpress
TranscriptomicsNew molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-66429 | biostudies-arrayexpress
TranscriptomicsNew molecular insights into modulation of platelet reactivity in aspirin-treated patients using a network-based approach [NanoString]
Platelet reactivity (PR) in cardiovascular (CV) patients is variable between individuals and modulates clinical outcome. However, the determinants of platelet reactivity are largely unknown. Integration of data derived from high-throughput omics technologies may yield novel insights into the molecul...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-66427 | biostudies-arrayexpress
TranscriptomicsCharacterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.
Recent technological advances have made transcriptome sequencing (RNA-seq) possible in cells with low RNA copy number including platelets. Resulting studies have used RNA-seq in platelets isolated from healthy individuals to characterize the platelet transcriptome. However, platelets, possibly throu...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-65705 | biostudies-arrayexpress
GenomicsScreening on Platelet Non-coding RNA Expression Profiles Discloses Its Correlations with Low Residual Platelet Reactivity
Screening on Platelet Non-coding RNA Expression Profiles Discloses Its Correlations with Low Residual Platelet Reactivity
PRJNA540474 | ENA
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