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MetabolomicsGolgi-IP, a tool for multimodal analysis of Golgi molecular content
The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis. It represents a central trafficking hub that sorts proteins and lipids to various destinations or for secretion from the cell. The Golgi has emerged as a docking platform for cellular signaling pathways inc...
2023-06-27 | MTBLS6511 | MetaboLights
MetabolomicsMetabolomics analysis was used to resolve metabolites affecting the protein oil content of soybean.
Soybean (Glycine max (L.)) originated in China more than 5000 years ago, and the country is currently the third largest producer of soybeans in the world (Hymowitz et al., 2015). Based on a wild soybean Chromosome Segment Substitution Line (CSSL) population were constructed by crossing with the cult...
2024-11-13 | MTBLS9424 | MetaboLights
TranscriptomicsIsocaloric intake of diets differing in macronutrient content (high protein or high fat) in adult rats indicate adverse effects as analysed by hepatic transcriptomics
Intake of high-protein (HP) diets has increased over the last years, mainly due to their popularity for body weight control. Liver is the main organ handling ingested macronutrients and it is associated with the beginning of different pathologies. We aimed to deepen our knowledge on molecular pathwa...
ORGANISM(S): Rattus norvegicus 
2017-05-02 | E-GEOD-57858 | biostudies-arrayexpress
MetabolomicsSmall auxin-up RNA promotes GmMYB176 gene transcription to modulate soybean isoflavone content

Isoflavones have been widely studied because of their potential health benefits, including antioxidant, anti-inflammatory, and anticancer properties. Soybeans (Glycine max (L.) Merr) are an effective source of natural isoflavones in humans. Therefore, it is important to cultivate varieties showin...

2025-06-23 | MTBLS12627 | MetaboLights
TranscriptomicsTranscription profiling of human blood cells after high protein and high carbohydrate breakfasts
Our aim was to evaluate the potential of gene expression profiling in blood in a human intervention study investigating the effect of two breakfasts with different macronutrient content on hormonal regulation of satiety. As dietary protein appears to be more satiating than dietary carbohydrate, we t...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-TABM-271 | biostudies-arrayexpress
TranscriptomicsHigh dietary protein decreases fat deposition induced by high-fat and high-sucrose diet in rats
High-protein diets are known to reduce adiposity in the context of high carbohydrate and Western diets. However, few studies have investigated the specific high-protein effect on lipogenesis induced by a high-sucrose (HS) diet or fat deposition induced by high-fat feeding. We aimed to determine the ...
ORGANISM(S): Rattus norvegicus 
2015-09-01 | E-GEOD-47570 | biostudies-arrayexpress
MetabolomicsImpact of collection conditions on the metabolite content of human urine samples as analyzed by liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy (LC-MS assay)
There is a lack of comprehensive studies documenting the impact of sample collection conditions on metabolic composition of human urine. To address this issue, two experiments were performed at a three-month interval, in which midstream urine samples from healthy individuals were collected, pooled, ...
2014-12-18 | MTBLS148 | MetaboLights
TranscriptomicsRNA-seq of soybean lines varying in oil composition and content
Genetic/genome diversity underlying variation in seed oil composition and content among soybean varieties is largely attributed to differences in transcript sequences and/or transcript accumulation of oil production related genes in seeds. Discovery and analysis of sequence and expression variations...
ORGANISM(S): Glycine max 
2016-01-13 | E-GEOD-56297 | biostudies-arrayexpress
TranscriptomicsEffect of downregulation of the high grain protein content (GPC) gene on the wheat transcriptome during monocarpic senescence
When GPC transcription factor in hexaploid wheat is down-regulated by stable RNA interference (GPC RNAi), senescence is significantly delayed and grain protein content together with the overall nutrient partitioning to the grain is greatly reduced. mRNA-seq was used to catalogue the genes that are r...
ORGANISM(S): Triticum aestivum 
2011-09-23 | E-GEOD-25759 | biostudies-arrayexpress
GenomicsHigh- and low-protein diet: effects on human hepatic fat content, autophagy, mitochondrial function and fat metabolism
High- and low-protein diet: effects on human hepatic fat content, autophagy, mitochondrial function and fat metabolism
PRJNA558947 | ENA
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