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TranscriptomicsImmortalization capacity of HPV types is inversely related to chromosomal instability in immortal descendants.
Human papillomavirus (HPV) induced immortalization of human foreskin keratinocytes (HFK) is a two-step process, including 1) the bypass of replicative senescence and acquisition of an extended lifespan, and 2) the outgrowth of immortal cells. Our previous study showed that the immortalization capaci...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-72063 | biostudies-arrayexpress
TranscriptomicsIdentification of markers associated with deregulated hTERT during HPV-medaited transformation
Although high-risk human papillomavirus (HPV) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. One key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit hTERT. Our previo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-8288 | biostudies-arrayexpress
TranscriptomicsHigh risk HPV infection effect on expression profile mediated by tumor necrosis factor
Previous studies have shown that normal and HPV immortalized keratinocytes are sensitive to TNF anti-proliferative effect. Conversely, HPV18-immortalized keratinocytes are resistant to the cytostatic effect mediated by this cytokine. In this study we have compared gene expression patterns in primary...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-4524 | biostudies-arrayexpress
TranscriptomicsHPV-related methylation in Oropharyngeal squamous cell carcinomas (OPSCC)
Using MCIp, we enriched highly methylated DNA from a normal mucosa control and from three OPSCC patient subgroups regarding the HPV status: group A, DNA-RNA- (Tu1-Tu5); group B, DNA+RNA- (Tu6-Tu10); group C, DNA+RNA+ (Tu11-Tu15). 3 groups of tumor biopsies, 5 samples each regarding HPV status: DNA-R...
ORGANISM(S): Homo sapiens 
2013-09-16 | E-GEOD-41152 | biostudies-arrayexpress
TranscriptomicsGenome-wide LOH and DNA copy number alteration in HPV-neg OSCC and their associations with disease-specific survival
Oral squamous cell carcinoma (OSCC) is associated with high case-fatality. To gain insight into the complexity of OSCC and to identify potential chromosomal changes that may be associated with OSCC mortality, we examined paired DNA from peripheral blood and tumor cells to assess genome-wide LOH and ...
ORGANISM(S): Homo sapiens 
2016-03-23 | E-GEOD-68717 | biostudies-arrayexpress
TranscriptomicsMicroRNA analysis in HPV-positive and HPV-negative cervical cancer cell lines
Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, includ...
ORGANISM(S): Homo sapiens 
2018-01-16 | E-MTAB-6361 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis in HPV(-) and HPV(+) squamous cell carcinoma cell lines
Human papillomavirus (HPV)-associated head and neck cancers (HNSCCs) have a distinct risk profile and appreciate a prognostic advantage compared to HPV-negative HNSCC. Promoter hypermethylation has been widely recognized as an important mechanism in the progression of HNSCC, but the extent to which ...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-24087 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumours.
Purpose: Human papilloma virus (HPV) associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than HPV(-) negative cancer. This may be due, in part, to the higher number of tumour infiltrating lymphocytes (TIL) in HPV(+) tumours. We used RNAseq to evaluate whether these differ...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-72536 | biostudies-arrayexpress
TranscriptomicsIdentification of a subgroup of head and neck cancers lacking numerical chromosomal aberrations
ABSTRACT Two major subgroups of head and neck squamous cell carcinomas (HNSCC) are currently distinguished based on etiology and pattern of genetic alterations; tumors with biologically active human papillomavirus (HPV) and tumors without. It is at present unclear whether additional genetically dist...
ORGANISM(S): Homo sapiens 
2009-03-11 | E-GEOD-11929 | biostudies-arrayexpress
TranscriptomicsComparative miRNA analysis between HPV (human papilloma virus)+ and HPV- oropharyngeal cancer
Oropharyngeal cancers have 2 main etiologies : High risk HPV (human papilloma virus) and tobacco/alcohol. The aim of this work is to find a miRNA signature specific to HPV induced oropharyngeal cancers
ORGANISM(S): Homo sapiens 
2015-05-12 | E-MTAB-3410 | biostudies-arrayexpress
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