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MetabolomicsImproving the Screening Analysis of Pesticide Metabolites in Human Biomonitoring by Combining High-Throughput In Vitro Incubation and Automated LC-HRMS Data Processing
There is a current need to monitor human exposure to a large number of pesticides and other chemicals of emerging concern (CECs). This requires screening analysis with high confidence for these compounds and their metabolites in complex matrices, which is hampered by the fact that no reference stand...
2022-01-17 | MTBLS2402 | MetaboLights
MetabolomicsHigh-Throughput Detection of an Alkaloidal Plant Metabolome in Plant Extracts Using LC-ESI-QTOF-MS.
Plant alkaloids represent a diverse group of nitrogen-containing natural products. These compounds are considered valuable in drug discovery and development. High-throughput identification of such plant secondary metabolites in complex plant extracts is essential for drug discovery, lead optimizatio...
2023-12-12 | MTBLS2914 | MetaboLights
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
MetabolomicsInvestigation of the threonine metabolism of Echinococcus multilocularis: EmTDH as a potential drug target in alveolar echinococcosis
Alveolar echinococcosis is a severe zoonotic disease caused by the fox tapeworm E. multilocularis. New treatment options are urgently needed. Whole-organism-based screening allows the discovery of potential new anti-echinococcal compounds, but suffers from low- to medium-throughput. An alternative a...
2026-09-14 | MTBLS10738 | MetaboLights
ProteomicsPhenotypic quantitative high throughput screening with Caenorhabditis elegans
Quantitative high throughput screening (qHTS) pharmacologically evaluates libraries of drugs and investigational agents for potential therapeutic uses, toxicological risk assessment, and increasingly for academic chemical tool discovery. Phenotypic HTS assays aim to interrogate molecular pathways a...
ORGANISM(S): Caenorhabditis elegans 
2023-05-30 | PXD027733 | Pride
Model organisms Laser cytometry Drug discovery Infectious disease Genetic disorders High-throughput screening 
ModelsRahman2022 - High throughput antibacterial screening with machine learning.
Prediction of antimicrobial potential using a dataset of 29537 compounds screened against the antibiotic resistant pathogen Burkholderia cenocepacia. The model uses the Chemprop Direct Message Passing Neural Network (D-MPNN) and has an AUC score of 0.823 for the test set. It has been used to virtual...
2024-04-22 | MODEL2404080002 | BioModels
Machine Learning Model Ersilia 
GenomicsHigh-throughput Drug Screening Identifies Ketotifen as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
High-throughput Drug Screening Identifies Ketotifen as a Potential Therapeutic Agent for Neuroendocrine Prostate Cancer
PRJNA933562 | ENA
GenomicsDrug repurposing via ultra-high throughput 3D spheroids screening in rare cancer treatment
Drug repurposing via ultra-high throughput 3D spheroids screening in rare cancer treatment
PRJNA1478839 | ENA
ProteomicsExploring the mechanism of contact-dependent cell-cell communication on chemoresistance based on single-cell high-throughput drug screening platform
In this study, we developed a microfluidic chip for single-cell high-throughput combined drug screening, and investigated the molecular mechanisms potentially impacted by CDCCC using quantitative mass spectrometry-based proteomics.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047031 | Pride
Tumor single cells High-throughput drug screening Microfluidic chip Quantitative proteomics Contact-dependent cell-cell communication 
UnknownDevelopment of a high-throughput screening-compatible assay for the discovery of inhibitors of the AF4-AF9 interaction using AlphaScreen technology.
Not available
S-EPMC3656630 | biostudies-literature
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