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MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
ProteomicsMethod development for simplified High-Throughput Plasma Proteomics
We developed a simplified proteomics sample preparation method that increased the sensitivity and reproducibility of large-scale plasma samples. Peptide loss was reduced while sensitivity was increased by eliminating the peptide clean-up step and using disposable trap column tips. The simplified Hig...
ORGANISM(S): Homo sapiens (Human) 
2023-04-03 | PXD038669 | Pride
Shtpp Simplified high-throughput plasma proteomics 
MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
ProteomicsHigh-throughput plasma/serum proteomics by coupling nanoparticle protein corona-based sample preparation and capillary zone electrophoresis-tandem mass spectrometry
A high-throughput workflow for bottom-up proteomics (BUP) of human plasma using capillary zone electrophoresis-tandem mass spectrometry (CZE-MS/MS) and nanoparticle protein corona-assisted sample preparation is presented. The streamlined approach enabled the identification and quantification of hun...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-08-04 | PXD063043 | Pride
Nanoparticle protein corona Bottom-up proteomics High-throughput Cze-ms/ms Biomarker 
ProteomicsHigh-throughput proteomics platform for clinical applications
Clinical proteomics holds the promise to accelerate the discovery of disease biomarkers, as well as to predict disease trajectories. Here we present a new platform for high-throughput plasma and serum proteomics, which combines an automated sample preparation workflow, robust high-flow liquid chroma...
ORGANISM(S): Homo sapiens (Human) 
2020-06-09 | PXD018874 | Pride
Plasma Serum Clinical proteomics High-throughput proteomics 
ProteomicsEvaluation of Olink Reveal Proximity Extension Assay for High-Throughput Proteomics: A Case Study Using NIST SRM 1950 and Spike-In Protein Standards
Plasma proteomics has regained attention in recent years through advancements in mass spectrometry instrumentation and sample preparation, as well as new high-throughput affinity-based technologies. Here, we evaluate the analytical performance of the new Olink Reveal platform, a proximity extension ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-03 | PAD000009 | Pride
Affinity proteomics Plasma Olink reveal 
UnknownCombination of automated sample preparation and micro-flow LC-MS for high-throughput plasma proteomics.
Not available
S-EPMC9824974 | biostudies-literature
UnknownExSTA: External Standard Addition Method for Accurate High-Throughput Quantitation in Targeted Proteomics Experiments.
Not available
S-EPMC6084352 | biostudies-literature
ProteomicsHigh-throughput mass spectrometry maps the sepsis plasma proteome and differences in response
THREE ARE SOME TECH PROBLEMS WHICH WILL BE SOLVED SOON! Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is an unmet global health challenge. Here we apply high-throughput tandem mass spectrometry to delineate the plasma proteome for 2622 sepsis and com...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD039875 | Pride
Proteomics Mass spectrometry Plasma Sepsis Transcriptomics Sub-phenotyping Precision medicine 
UnknownA Streamlined High-Throughput Plasma Proteomics Platform for Clinical Proteomics with Improved Proteome Coverage, Reproducibility, and Robustness.
Not available
S-EPMC10080683 | biostudies-literature
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