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MetabolomicsDiversity in DNA: Identification of methylated deoxyadenosines in higher eukaryotes
Since the discovery that cytosine deoxynucleotides could be methylated (dC5m), not much is known in higher eukaryotes about modifications affecting other deoxynucleotides. Here, we now report that we detected N-6-methyl-deoxyadenosine (dA6m) not only in frog DNA, but also in other species including ...
2015-11-16 | MTBLS276 | MetaboLights
GenomicsDifferential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus
Higher order chromatin structure establishes domains that organize the genome and coordinate gene expression. However, the molecular mechanisms controlling transcription of individual loci within a topological domain (TAD) are not fully understood. The cystic fibrosis transmembrane conductance reg...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-74709 | biostudies-arrayexpress
MetabolomicsFunctional metabolomics as a tool to analyze Mediator function and structure in plants
Mediator is a multiprotein transcriptional co-regulator complex composed of four modules; Head, Middle, Tail, and Kinase. It conveys signals from promoter-bound transcriptional regulators to RNA polymerase II and thus plays an essential role in eukaryotic gene regulation. We describe subunit localiz...
2018-01-30 | MTBLS450 | MetaboLights
GenomicsRegulation of somatic hypermutation by higher-order chromatin structure
Regulation of somatic hypermutation by higher-order chromatin structure
PRJNA1132192 | ENA
TranscriptomicsRUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.
RUNX1 is a transcription factor functioning both as an oncogene and a tumor suppressor in breast cancer. RUNX1 alters chromatin structure in cooperation with chromatin modifier and remodeling enzymes. In this study, we examined the relationship between RUNX1-mediated transcription and genome organiz...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-75070 | biostudies-arrayexpress
GenomicsRegulation of somatic hypermutation by higher-order chromatin structure [PRO-Seq]
Regulation of somatic hypermutation by higher-order chromatin structure [PRO-Seq]
PRJNA1141908 | ENA
GenomicsRegulation of somatic hypermutation by higher-order chromatin structure [Tri-C]
Regulation of somatic hypermutation by higher-order chromatin structure [Tri-C]
PRJNA1141913 | ENA
GenomicsRegulation of somatic hypermutation by higher-order chromatin structure [ChIP-Seq]
Regulation of somatic hypermutation by higher-order chromatin structure [ChIP-Seq]
PRJNA1132194 | ENA
GenomicsRegulation of somatic hypermutation by higher-order chromatin structure [MutPE-Seq]
Regulation of somatic hypermutation by higher-order chromatin structure [MutPE-Seq]
PRJNA1132196 | ENA
GenomicsRNA duplex map in living cells reveals higher order transcriptome structure
RNA duplex map in living cells reveals higher order transcriptome structure
PRJNA299809 | ENA
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