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MetabolomicsDiagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.

Study question: Can a novel machine learning pipeline create predictive models that identify a composite biomarker to differentiate live normally sited pregnancies (LNSP) from non-viable pregnancies in women presenting with pain and/or bleeding in early gestation?

Summary answer: Serum met...

2025-08-14 | MTBLS6219 | MetaboLights
TranscriptomicsTranscription profiling of time series of C.elegans mutants and wild type
This series of samples comprises multiple early embryonic time courses for C. elegans. Time courses consisting of 10 time points each for 4 different genotypes are included: wild-type (strain N2 grown on E. coli strain OP50), pie-1(zu154) (progeny of homozygous mutant mothers [Unc] of strain JJ532 g...
ORGANISM(S): Caenorhabditis elegans 
2007-07-31 | E-GEOD-2180 | biostudies-arrayexpress
TranscriptomicsDevelopment and Independent Validation of a Molecular Subtype in High Grade Serous Ovarian Cancer using Formalin Fixed Paraffin Embedded Tissue, Training set
High Grade Serous Ovarian Cancer (HGSOC) is a histopathological diagnosis and may represent multiple diseases at a molecular level. We investigated whether distinct molecular subgroups may influence treatment choice. The accompanying validation set of data has also been deposited in ArrayExpress und...
ORGANISM(S): Homo sapiens 
2020-12-21 | E-MTAB-2562 | biostudies-arrayexpress
TranscriptomicsDevelopment and Independent Validation of a Molecular Subtype in High Grade Serous Ovarian Cancer using Formalin Fixed Paraffin Embedded Tissue, Validation set
High Grade Serous Ovarian Cancer (HGSOC) is a histopathological diagnosis and may represent multiple diseases at a molecular level. We investigated whether distinct molecular subgroups may influence treatment choice. The accompanying training set of data has also been deposited in ArrayExpress under...
ORGANISM(S): Homo sapiens 
2021-12-21 | E-MTAB-2570 | biostudies-arrayexpress
TranscriptomicsA study of transcriptome response to salt treatment across three zones of the root in a barley landrace and malting cultivar
Paired-end RNA-Seq libraries were constructed for three root sections of the roots of barley cv. Clipper, and landrace Sahara, grown under control and salt-treated (100 mM NaCl) conditions on agar plates in quadruplicate. Experiments were conducted in a temperature-controlled growth cabinet at 17 C ...
ORGANISM(S): Hordeum vulgare 
2016-06-27 | E-MTAB-4634 | biostudies-arrayexpress
TranscriptomicsA Local Regulatory Network Around Three NAC Transcription Factors in Stress Responses and Senescence in Arabidopsis leaves (Botrytis cinerea infection).
A network model has been generated that describes the immediate gene expression cascade surrounding three similar but distinct NAC transcription factors that have roles to play in leaf senescence and in many stress responses in Arabidopsis. ANAC019, ANAC055 and ANAC072 belong to the same clade of N...
ORGANISM(S): Arabidopsis thaliana 
2013-04-23 | E-GEOD-45594 | biostudies-arrayexpress
TranscriptomicsA Local Regulatory Network Around Three NAC Transcription Factors in Stress Responses and Senescence in Arabidopsis leaves (expression between lines at timepoints).
A network model has been generated that describes the immediate gene expression cascade surrounding three similar but distinct NAC transcription factors that have roles to play in leaf senescence and in many stress responses in Arabidopsis. ANAC019, ANAC055 and ANAC072 belong to the same clade of N...
ORGANISM(S): Arabidopsis thaliana 
2013-04-23 | E-GEOD-45183 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human dendritic cells matured by cadherin reveals disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation
The maturation of dendritic cells (DCs) after exposure to microbial products or inflammatory mediators plays a critical role in initiating the immune response. We found that maturation can also occur under steady state conditions, triggered by alterations in E-cadherin-mediated DC-DC adhesion. Sele...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of activated mixed glial (microglia) and monocyte-derived macrophages
Since macrophage activation can now be studied at a global level using modern microarray and proteomic analyses, discovery of novel macrophage activation genes is inevitable and important for understanding HIV-associated dementia (HAD). We isolated two different types of primary human macrophages, m...
ORGANISM(S): Homo sapiens 
2007-08-29 | E-GEOD-1910 | biostudies-arrayexpress
MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
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