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MetabolomicsMetabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
The relationship between sequence variation and phenotype is poorly understood. Here, we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phenotype of E. coli strains that carry destabilizing mutations in dihydrofolate reductase (DHFR). We find that partial lo...
2021-06-30 | MTBLS2795 | MetaboLights
UnknownGenotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study.
Not available
S-EPMC3158597 | biostudies-literature
ModelsMackenzie1996_NaGlucoseCotransporter_Kidney
This a model from the article: Biophysical characteristics of the pig kidney Na+/glucose cotransporter SGLT2 reveal a common mechanism for SGLT1 and SGLT2. Mackenzie B, Loo DD, Panayotova-Heiermann M, Wright EM. J Biol Chem 1996 Dec 20;271(51):32678-83...
2005-01-01 | MODEL1006230076 | BioModels
ProteomicsStructure of the Fanconi anaemia monoubiquitin ligase complex
The Fanconi Anemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks. Genetic inactivation of this pathway impairs development, prevents blood production and promotes cancer. The key molecular step in the FA pathway is the monoubiquitination of a heterodime...
ORGANISM(S): Gallus gallus (Chicken) 
2019-10-16 | PXD014282 | Pride
Fanconi anemia monoubiquitin ligase Human Crosslinking ms Em Electron microscopy Clms 
UnknownHigh-density lipoprotein receptor SCARB1 is required for carotenoid coloration in birds.
Not available
S-EPMC5441819 | biostudies-literature
UnknownEmergence of the Asian lineage of Zika virus in Angola: an outbreak investigation.
Not available
S-EPMC6892302 | biostudies-literature
UnknownEmbolism resistance supports the contribution of dry-season precipitation to transpiration in eastern Amazon forests.
Not available
S-EPMC12377737 | biostudies-literature
UnknownLong-term impacts of an urban sanitation intervention on enteric pathogens in children in Maputo city, Mozambique: study protocol for a cross-sectional follow-up to the Maputo Sanitation (MapSan) trial 5 years postintervention.
Not available
S-EPMC10254709 | biostudies-literature
UnknownThe bis-electrophile diepoxybutane cross-links DNA to human histones but does not result in enhanced mutagenesis in recombinant systems.
Not available
S-EPMC2696559 | biostudies-literature
UnknownHaemosporidians from a Neglected Group of Terrestrial Wild Birds in the Peruvian Amazonia.
Not available
S-EPMC9573858 | biostudies-literature
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