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MetabolomicsInteraction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways a...

2025-07-22 | MTBLS12761 | MetaboLights
UnknownHelicobacter pylori Reactivates Human Immunodeficiency Virus-1 in Latently Infected Monocytes with Increased Expression of IL-1β and CXCL8.
Not available
S-EPMC7290055 | biostudies-literature
ProteomicsIn situ ribosome clustering and ultrastructure reorganization of polar tube proteins in germinated microsporidia polar tube
During host cell invasion, microsporidia translocate their entire cytoplasmic contents through a thin, hollow superstructure known as the polar tube. To achieve this, the polar tube transitions from a compact spring-like state inside the environmental spore to a long needle-like tube capable of long...
ORGANISM(S): Vairimorpha necatrix 
2024-01-09 | PXD042571 | Pride
Ribosome Polar tube Polar tube proteins Microsporidia Cryo-electron tomography 
TranscriptomicsGene expression data from wild-type and Nlrc5 knockout GM-CSF induced bone marrow dendritic cells infected with Newcastle Disease virus.
Nlrc5 is encoding a Nod-like receptor protein NLRC5/NOD27. To check the involvement of Nlrc5 in antiviral response, we examined gene expression profile in wild-type and Nlrc5 knockout GM-CSF bone marrow macrophage with using microarrays. Bone marrow cells were cultured with GM-CSF and harvested on d...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-22448 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary macrophages treated with the chemotherapeutic agent, 5,6-dimethylxanthenone-4-acetic acid,
Vascular disrupting agents (VDA) represent a novel approach to the treatment of cancer, resulting in collapse of tumor vasculature and tumor death. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) is a VDA currently in advanced Phase II clinical trials, yet its precise mechanism of action is unknown de...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7194 | biostudies-arrayexpress
TranscriptomicsCandida albicans Microarray studies: CAP2 (Wild type) vs. cap2D (Homozygous null mutant)
Transcriptome profiling to identify Cap2/Hap43 regulons in the human fungal pathogen Candida albicans: Wild type vs. cap2D grown in iron-depleted medium Two-condition experiment, WT vs. cap2D cells. Biological replicates: Wild-type and cap2D, independently grown in iron-depleted medium and harvested...
ORGANISM(S): Candida albicans 
2011-05-24 | E-GEOD-28429 | biostudies-arrayexpress
UnknownMulticentric validation of the proof of concept for utility of Trueprep extracted DNA in line probe assay testing.
Not available
S-EPMC11999121 | biostudies-literature
TranscriptomicsGlobal Identification of Noncoding RNAs in S. cerevisiae
Genome-wide detection of novel non-coding RNAs in S. cerevisiae by modulating an RNase P pathway through the depletion of a component RPP1. Nearly 400,000 36-mer oligonucleotide probes, tiling the entire yeast genome including the mitochondrial chromosome with an average gap of 10 bases between two ...
ORGANISM(S): Saccharomyces cerevisiae 
2006-02-28 | E-GEOD-4275 | biostudies-arrayexpress
UnknownEpromoters bind key stress-related transcription factors to regulate clusters of stress response genes
Not available
S-SCDT-10_1038-S44318-025-00670-3 | biostudies-other
TranscriptomicsArabidopsis Whole Genome 36-mer
Identification of novel transcribed sequences in Arabidopsis thaliana using high density genome tiling arrays.
ORGANISM(S): Arabidopsis thaliana 
2005-02-09 | E-GEOD-2247 | biostudies-arrayexpress
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