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UnknownMolecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB.
Not available
S-EPMC2764309 | biostudies-literature
Genomics
Antibiotic resistance E. coli hipB KO strain
PRJNA1019295 | ENA
ProteomicsProteome dynamics in persisting and resuscitating bacterial cells
Bacterial persister cells become transiently tolerant to antibiotics by restraining their growth and metabolic activity. Detailed molecular characterization of bacterial persistence is hindered by low count of persisting cells and the need for their isolation. Here we used sustained addition of stab...
ORGANISM(S): Escherichia coli 
2021-07-30 | PXD018153 | Pride
Hipb Resuscitation Hipa Persistence Escherichia coli 
GenomicsMedium chain unsaturated fatty acid ethyl esters inhibit persister formation of Escherichia coli via antitoxin HipB
Medium chain unsaturated fatty acid ethyl esters inhibit persister formation of Escherichia coli via antitoxin HipB
PRJNA448156 | ENA
TranscriptomicsMedium chain unsaturated fatty acid ethyl esters inhibit persister formation of Escherichia coli via antitoxin HipB
Persisters represent a small bacterial population that is dormant and that survives under antibiotic treatment without experiencing genetic adaptation. Persisters are also considered one of the major reasons for recalcitrant chronic bacterial infections. Although several mechanisms of persister form...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2018-08-08 | GSE112545 | GEO
ProteomicsSerine-Threonine Kinase Encoded by a Split hipA Homologous Gene of Escherichia coli Inhibits Tryptophanyl-tRNA Synthetase
Type II toxin – antitoxin modules encode a stable toxin that inhibits translation, replication or cell wall synthesis and an unstable protein antitoxin that neutralizes the toxin by direct protein – protein contact. The hipBA module of Escherichia coli K-12 codes for HipA, a eukaryote-like serine/th...
ORGANISM(S): Escherichia coli 
2019-06-24 | PXD012023 | Pride
E. coli Kinase Phosphorylation 
UnknownThe Haemophilus influenzae HipBA toxin-antitoxin system adopts an unusual three-com-ponent regulatory mechanism.
Not available
S-EPMC9438503 | biostudies-literature
UnknownThe bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence.
Not available
S-EPMC4150777 | biostudies-literature
UnknownHipBA-promoter structures reveal the basis of heritable multidrug tolerance.
Not available
S-EPMC7502270 | biostudies-literature
UnknownSerine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase.
Not available
S-EPMC6581861 | biostudies-literature
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