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TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
ModelsShin2016 - Unveiling Hidden Dynamics of Hippo Signalling
This is a mathematical model describing Hippo signalling pathway activity. It includes descriptions of crosstalk with the Akt and ERK MAPK pathways; crosstalk activity is described using complex regulatory mechanisms comprised of competitive protein-protein interactions and phosphorylation mediated ...
2024-09-02 | BIOMD0000000832 | BioModels
TranscriptomicsTranscriptional profiling of mouse inner cell mass of the blastocyst, primordial germ cells and cultured pluripotent stem cells
Pluripotent stem cells are derived from culture of early embryos or the germline, and can be induced by reprogramming of somatic cells. Barriers to reprogramming are expected to exist that stabilize the differentiated state and have tumor suppression functions. However, we have a limited understandi...
ORGANISM(S): Mus musculus 
2012-01-31 | E-GEOD-35416 | biostudies-arrayexpress
TranscriptomicsGene expression profiles regulated by Tead2 mutants, Yap, and cell density in NIH3T3 cells
Regulation of organ size is important for development and tissue homeostasis. In Drosophila, Hippo signaling controls organ size by regulating the activity of a TEAD transcription factor, Scalloped, through modulation of its coactivator protein Yki. The role of mammalian Tead proteins in growth r...
ORGANISM(S): Mus musculus 
2008-11-20 | E-GEOD-12498 | biostudies-arrayexpress
TranscriptomicsCardiac gene expression profiling of Salvador mutant mice
In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cr...
ORGANISM(S): Mus musculus 
2011-02-12 | E-GEOD-27259 | biostudies-arrayexpress
TranscriptomicsCardiac gene expression profiling of neonatal Salvador mutant mice
In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cr...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-44103 | biostudies-arrayexpress
GenomicsThe Hippo tranducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation
The Hippo pathway effector YAP1 controls stem cell fate in epithelial tissues, but its role in stem cells of non-epithelial tissues, such as skeletal muscle, is poorly documented. Here we show that sustained YAP1 activity in mouse activated satellite cells in vivo induces rhabdomyosarcoma (RMS) rese...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-55186 | biostudies-arrayexpress
TranscriptomicsHippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
The Hippo signaling pathway has become recognized as a context-dependent regulator of cell proliferation, differentiation, and apoptosis in species ranging from Drosophila to human. In this study, we sought to understand whether Hippo signaling plays a role in pancreatic development and organ homeos...
ORGANISM(S): Mus musculus 
2013-02-14 | E-GEOD-44298 | biostudies-arrayexpress
ProteomicsHuman Hippo cancer mutation proteins TAP-LC-MS
The Hippo pathway is a commonly altered signaling pathway involved in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development has not been fully understood. In this study, we systematically analyzed the Hippo somatic mutations der...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD049472 | Pride
Somatic mutations Cancer The hippo pathway 
GenomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq]
Background—YAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the d...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57717 | biostudies-arrayexpress
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