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TranscriptomicsPAX3-FOXO1 suppresses cellular senescence through RASSF4-mediated restraint of the mammalian Hippo/MST1 pathway
Alveolar rhabdomyosarcoma (aRMS) is an aggressive sarcoma of skeletal muscle characterized by expression of the PAX3-FOXO1 fusion gene. Despite its discovery over almost 20 years ago, PAX3-FOXO1 remains an enigmatic tumor driver. Previously, we reported that PAX3-FOXO1 supports aRMS initiation by en...
ORGANISM(S): Homo sapiens 
2014-05-15 | E-GEOD-40543 | biostudies-arrayexpress
TranscriptomicsCardiac gene expression profiling of Salvador mutant mice
In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cr...
ORGANISM(S): Mus musculus 
2011-02-12 | E-GEOD-27259 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse inner cell mass of the blastocyst, primordial germ cells and cultured pluripotent stem cells
Pluripotent stem cells are derived from culture of early embryos or the germline, and can be induced by reprogramming of somatic cells. Barriers to reprogramming are expected to exist that stabilize the differentiated state and have tumor suppression functions. However, we have a limited understandi...
ORGANISM(S): Mus musculus 
2012-01-31 | E-GEOD-35416 | biostudies-arrayexpress
ProteomicsHuman Hippo pathway , LC-MSMS - Defining the protein-protein interaction network of the human Hippo pathway
The Hippo pathway, which is conserved from Drosophila to mammals, has been recognized as a tumor suppressor signaling pathway governing cell proliferation and apoptosis, two key events involved in organ size control and tumorigenesis. Although several upstream regulators, the conserved kinase cascad...
ORGANISM(S): Homo sapiens (Human) 
2013-10-17 | PXD000415 | Pride
Protein interactome Tandem affinity purification Hippo pathway 
ProteomicsDynamic phosphoproteomics of BRS3 activation reveals Hippo signaling pathway for cell migration
Bombesin receptor subtype-3 (BRS3) is an orphan G-protein coupled receptor (GPCR) that involved in a range of pathological and physiological processes, while its biological functions and underlying regulatory mechanisms remain largely unknown. Quantitative phosphoproteomics approach was employed in ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-12 | PXD035666 | Pride
Phosphoproteomics Hippo signaling pathway Signaling transductions Gpcr Cell migration 
ProteomicsHuman Hippo cancer mutation proteins TAP-LC-MS
The Hippo pathway is a commonly altered signaling pathway involved in cancer initiation and progression; however, exactly how this pathway becomes dysregulated to promote human cancer development has not been fully understood. In this study, we systematically analyzed the Hippo somatic mutations der...
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD049472 | Pride
Somatic mutations Cancer The hippo pathway 
ModelsShin2016 - Unveiling Hidden Dynamics of Hippo Signalling
This is a mathematical model describing Hippo signalling pathway activity. It includes descriptions of crosstalk with the Akt and ERK MAPK pathways; crosstalk activity is described using complex regulatory mechanisms comprised of competitive protein-protein interactions and phosphorylation mediated ...
2024-09-02 | BIOMD0000000832 | BioModels
TranscriptomicsCardiac gene expression profiling of neonatal Salvador mutant mice
In this study, we identified a number of genes whose expression are regulated by the Hippo tumor suppressor pathway. To disrupt Hippo signaling in the mouse heart, we inactivated the single mammalian Salv ortholog using a Salv conditional null allele and the Nkx2.5 cre allele that directs cardiac cr...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-44103 | biostudies-arrayexpress
TranscriptomicsHippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
The Hippo signaling pathway has become recognized as a context-dependent regulator of cell proliferation, differentiation, and apoptosis in species ranging from Drosophila to human. In this study, we sought to understand whether Hippo signaling plays a role in pancreatic development and organ homeos...
ORGANISM(S): Mus musculus 
2013-02-14 | E-GEOD-44298 | biostudies-arrayexpress
GenomicsPi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival [ChIPseq]
Background—YAP, the nuclear effector of Hippo signaling, regulates cellular growth and survival in multiple organs, including the heart, by interacting with TEAD sequence specific DNA-binding proteins. Recent studies showed that YAP stimulates cardiomyocyte proliferation and survival. However, the d...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-57717 | biostudies-arrayexpress
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