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MetabolomicsEarly-life social experiences remodel hippocampal glycerophospholipid metabolism linked to adult memory

Early-life experiences profoundly shape brain development and long-term cognition. Environmental enrichment (EE) and social isolation (SI) represent opposing forms of stimulation and deprivation, yet the metabolic mechanisms connecting these conditions to cognitive outcomes remain poorly defined....

2025-12-04 | MTBLS13454 | MetaboLights
MetabolomicsTherapeutic Effect of Buyang Huanwu Decoction on the Gut Microbiota and Hippocampal Metabolism in a Rat Model of Cerebral Ischemia

Buyang Huanwu decoction (BHD) is a well-known Chinese herbal prescription. It has been widely used in the clinical treatment of cerebral ischemia (CI) in China. However, the mechanism underlying the treatment of CI with BHD remains to be elucidated. In this study, we combined microbiomic and meta...

2022-06-02 | MTBLS4366 | MetaboLights
MetabolomicsInhibition of stress resilience and adult hippocampal neurogenesis by platelet-derived LPA16:0 in anxiety

Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 l...

2026-02-05 | MTBLS13589 | MetaboLights
MetabolomicsUnraveling the Mechanisms of Propofol-Induced Psychological Dependence: A Multi-Omics Approach Linked to Gut Microbiota in Hippocampal Function

Introduction: Drug abuse is becoming a global public health crisis. According to the United Nations, the number of drug users worldwide has increased dramatically over the past decade, with a surge in the number of drug abusers. The problem was exacerbated by the expanding market for illicit drug...

2025-05-12 | MTBLS12337 | MetaboLights
TranscriptomicsIdentification of the miRNA targetome in hippocampal neurons using RIP-seq
We established a neuron-specific Argonaute2:GFP-RNA immunoprecipitation followed by high throughput sequencing (AGO2-RIP-seq) to analyse the regulatory role of miRNAs in mouse hippocampal neurons. Using this technique, we identified more than two thousand miRNA target genes in hippocampal neurons, r...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-65543 | biostudies-arrayexpress
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
TranscriptomicsStudy on miRNA expression pattern in Aging Mouse Hippocampal Neurons
Mouse hippocampal microRNA 3 samples
ORGANISM(S): Mus musculus 
2016-10-27 | E-GEOD-74796 | biostudies-arrayexpress
MetabolomicsInsights from hippocampal neurogenesis and brain tumor development in a mouse model of experimental colitis induced by dextran sodium sulfate
Not available
ORGANISM(S): Mus musculus 
ST002275 | MetabolomicsWorkbench
no omics definedTranscription profiling of human hippocampi from epilepsy patients with and without hippocampal sclerosis and autopsy controls
Genome wide gene expression was compared between nonHS, HS temporal lobe epilepsy patients (TLE) and autopsy control hippocampi in a 3-way analysis. In many TLE patients the hippocampus is subject to massive neuronal damage, gliosis and hippocampal sclerosis (HS), while in others there is no apparen...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-MEXP-744 | biostudies-arrayexpress
TranscriptomicsCalorie restriction suppresses age-dependent hippocampal transcriptional signatures.
Calorie restriction (CR) enhances longevity and mitigates aging phenotypes in numerous species. Physiological responses to CR are cell-type specific and variable throughout the lifespan; however, the mosaic of molecular changes responsible CR benefits remain unclear, particularly in brain regions su...
ORGANISM(S): Mus musculus 
2015-07-14 | E-GEOD-69952 | biostudies-arrayexpress
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