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ProteomicsHistidine to glutamine substitutants, a regulated process that impacts cell survival and pinpoints histidine shortage in cancer
Cancer-associated genetic, epigenetic, and microenvironmental factors enforce tryptophan and arginine shortages that induce specific codon reassignments (substitutants) in their proteomes. Evidence for the impact of shortages of other amino acids on cancer translation is lacking. Here, we investigat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD060514 | Pride
Substituants Histidine shortage Glutamine Proteome Cancer 
GenomicsHistidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer
Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer
PRJNA1463687 | ENA
TranscriptomicsHistidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer
Cancer-associated genetic, epigenetic, and microenvironmental factors impose shortages of tryptophan and arginine, which induce specific codon reassignments (substitutants) in their proteomes. Whether cancers are deprived of other amino acids is unknown. Histidine is an essential amino acid reported...
ORGANISM(S): Homo sapiens 
2026-06-29 | GSE330343 | GEO
UnknownThe Zur-regulated ZinT protein is an auxiliary component of the high-affinity ZnuABC zinc transporter that facilitates metal recruitment during severe zinc shortage.
Not available
S-EPMC2832539 | biostudies-literature
ProteomicsGrowth in Low Carbon Conditions Reveals Amino-Acid-Coupled Iron Uptake
Bacteria in nature encounter substrates at widely varying concentrations, yet studies of bacterial physiology have focused more on nutrient type than concentration, partly due to challenges in maintaining low concentrations. We developed a Millifluidic Continuous Culture Device (MCCD) to culture bac...
ORGANISM(S): Escherichia coli Bacteria 
2026-09-09 | PXD059988 | Pride
Lc-msms E. coli Iron uptake 
TranscriptomicsRegulatory Mutations Affecting Sulfur Metabolism Induce Environmental Stress Response in Aspergillus nidulas
Mutations in the cysB, sconB and sconC genes affect sulfur metabolism in Aspergillus nidulans in different ways. Mutation of cysB blocks synthesis of cysteine by the main pathway leaving only the less effective alternative route. Mutations of sconB or sconC affect subunits of the SCF ubiquitin ligas...
ORGANISM(S): Aspergillus nidulans 
2014-02-14 | E-GEOD-54130 | biostudies-arrayexpress
UnknownCytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver.
Not available
S-EPMC6797707 | biostudies-literature
UnknownAssessment of Physiological Rat Kidney Ageing-Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation.
Not available
S-EPMC8875225 | biostudies-literature
UnknownReview: Metabolic Control of Immune System Activation in Rheumatic Diseases.
Not available
S-EPMC5711528 | biostudies-literature
UnknownResults of the TOP Study: Prospectively Randomized Multicenter Trial of an Ex Vivo Tacrolimus Rinse Before Transplantation in EDC Livers.
Not available
S-EPMC4946517 | biostudies-literature
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