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ProteomicsArginine to Cysteine substitutants in lung cancer enhance survival to chemotherapy
Tryptophan and arginine are the two most prominent restrictive amino acids linked to anti-tumor activity. For tryptophan, the induction of indoleamine 2,3-dioxygenase 1 (IDO1) by interferon-gamma (IFNg) secreted by T cells, catabolizes tryptophan to kynurenine to suppress T cell activity. For argini...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043612 | Pride
Arginine Substituants Keap1 Lung cancer Tryptophan 
ProteomicsAdoptive T cell therapy targeting a widespread inducible product of aberrant mRNA translation
Deregulated protein production by oncogenic pathways fuels tumor development. Consequently, the induction of tryptophan shortage by Indoleamine 2,3-Dioxygenase 1 (IDO1) enzyme, following interferon-gamma (IFNg) secretion by activated T cells, induces tryptophan to phenylalanine (W>F) substitutants1,...
ORGANISM(S): Homo sapiens (Human) 
2025-01-10 | PXD041893 | Pride
Substituants Adoptive t-cell therapy Mrna translation Immunopeptidomics 
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