Sort   by:  
 Page size 
MetabolomicsMolecular Docking and Dynamic Study of Ethanol Extract of Citrus sinensis as Keap-1 and NMDA inhibitor in Brain Injury

Traumatic brain injury is a significant cause of mortality in young adults and disability in all age groups. Secondary injury involving various processes such as oxidative stress, which induced neuronal apoptosis, ensued afterward. This study aimed to analyze the active compounds of Citrus sinens...

2023-01-02 | MTBLS5785 | MetaboLights
TranscriptomicsCharacterization of RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors the activity of Nrf2 is inhibited by its interaction with the kelch-like ECH-associated protei...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-71695 | biostudies-arrayexpress
ProteomicsIdentification and Characterization of MCM3 as a KEAP1 Substrate
KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is considered the primary function of KEAP1; however, few other KEAP1 substrates have been identified. Because KEAP1 is altered in a number of human ...
ORGANISM(S): Homo sapiens (Human) 
2017-10-12 | PXD003929 | Pride
Hek293t Di-gly Apms Silac Label free quantification 
ProteomicsNovel KEAP1 activator targeting C151 enhances CUL3 binding and decreases NRF2
Novel KEAP1 activator targeting C151 enhances CUL3 binding and decreases NRF2
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD056257 | Pride
Nrf2 Keap1 Cul3 
ProteomicsPatient-derived KEAP1 superbinder mutants stabilize KEAP1 structure and sequester NRF2 in p62-dependent clusters
Cancer-derived loss-of-function mutations in the KEAP1 tumor suppressor gene stabilize the NRF2 transcription factor, resulting in a pro-survival gene expression program that alters cellular metabolism and neutralizes oxidative stress. In a previous study of KEAP1 mutations observed in lung cancer, ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD008411 | Pride
Nrf2 Keap1 Superbinders P62 Clusters Mutations Lung cancer 
ProteomicsMitochondrial proteome from liver and intestinal organoids from WT, Nrf2 knockout and Keap1 knockdown mice
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH associated protein 1 (Keap1), are at the interface between redox and intermediary metabolism, allowing adaptation and survival under conditions of oxidative, inflammatory and m...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-11 | PXD021639 | Pride
Organoids Mitochondrial Keap1 Nrf2 Liver Mouse 
TranscriptomicsTranscription profiling of mouse liver from conditional Keap1 knockout mice vs. genetic control mice
To compare hepatic gene expression in conditional Keap1 knockout (Alb-Cre:Keap1(flox/-)) and genetic control mice. Disruption of Keap1-mediated repression of Nrf2 signaling was expected to result in increased expression of Nrf2-regulated genes. Experiment Overall Design: Hepatic gene expression was ...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-11287 | biostudies-arrayexpress
ProteomicsExploring Effectiveness of KEAP1-based PROTAC Strategy
Targeted protein degradation (TPD) uses small molecules to recruit E3 ubiquitin ligases into proximity of proteins of interest, inducing ubiquitination-dependent degradation. A major bottleneck in the TPD field is the lack of accessible E3 ligase ligands for developing degraders. To expand the E3 li...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-07 | PXD034423 | Pride
Brd4 Targeted protein degradation Keap1 Degrader Fak 
TranscriptomicsExpression changes between loricrin knockout and wildtype P0
The loss of loricrin, a major component of the cornified envelope, results in a delay of epidermal barrier formation. Therefore, the living layers of the epidermis are aberrantly exposed to late-stage amniotic fluid, which may serve as the signal to upregulate genes that functionally compensate for ...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-41742 | biostudies-arrayexpress
TranscriptomicsExpression data from Keap1 overexpression and Nrf2 knockdown lung cancer cell
Keap1 overexpressed and Nrf2 depleted CL1-5 cells were used to identify genes regulated by Keap1/Nrf2 axis-dependent gene regulations We used microarrays to detail the global programme of gene expression underlying metastasis and identified distinct classes of Keap1/Nrf2-regulated genes during this ...
ORGANISM(S): Homo sapiens 
2015-03-04 | E-GEOD-66473 | biostudies-arrayexpress
Sort   by:  
 Page size