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TranscriptomicsMetabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis
The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms by which stromal cells influence the tumor epithelium are poorly understood. The signaling adapter p62 has been implicated as a positive regulator of epithelial tumorigenesis; however, its role in the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-55587 | biostudies-arrayexpress
TranscriptomicsDepletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice
Huntington's disease (HD) is a dominantly inherited genetic disease caused by mutant huntingtin (htt) protein with expanded polyglutamine tracts. A neuropathological hallmark of HD is the presence of neuronal inclusions of mutant htt. p62 is an important regulatory protein in selective autophagy, ...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-62210 | biostudies-arrayexpress
ProteomicsSpecies-specific cleavage of the autophagy adaptor p62 dictates responses to TNF
Inflammation is a driver of many diseases including cancer. Several studies have also shown that changes to macroautophagy can affect inflammation. We were interested in these connections and we report here that the autophagy adaptor proteins p62/SQSTM1 is cleaved upon treatment with the inflammat...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD065587 | Pride
Autophagy Tnf Inflammation Caspase Protein cleavge Apoptosis P62 
ProteomicsAcetylation of p62 regulates base excision repair through interaction with APE1
p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD034901 | Pride
Sirt7 Ape1 P62 Base excision repair Acetylation Hmof 
ProteomicsAcetylation of p62 regulates base excision repair through interaction with APE1
p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD034899 | Pride
Sirt7 Ape1 P62 Base excision repair Acetylation Hmof 
ProteomicsQuantitative proteomics profilling of p62 droplet
Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms are still not fully understood. Mass spectrometry-based proteomics revealed significant enrichment of vesicle trafficking components within p62 bodies.
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2023-06-09 | PXD038262 |
Proteomicsp62/SQSTM1 tyrosine phosphorylation LC-MS/MS
Tyrosine phosphorylation sites on p62 were identified by mass spectrometry following co-immunoprecipitation of p62 overexpressed in HEK293T cells with wild-type Lck or a kinase-dead Lck mutant.
ORGANISM(S): Homo sapiens (Human) 
2026-07-07 | PXD078987 | Pride
Tyrosine phosphorylation P62/sqstm1 Lck 
ProteomicsProximity proteomics on RPE1 stable cell lines with miniTurbo-p62 and ATG5 Knock-down to investigate p62 filaments and calcium-rich p62-enwrapped lipid droplets
The selective autophagy receptor p62/SQSTM1 (from hereon p62) is known to form higher-order filaments in vitro and to undergo liquid-liquid phase separation when mixed with poly-ubiquitin. We determined the full-length cryo-EM structure of p62 and elucidated a structured double helical filament scaf...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066163 | Pride
Human Lc-ms Biotinylation Miniturbo Atg5 kd 
ProteomicsProteomic analysis of p62 bodies
Relative abundance of each protein in p62 bodies was calculated based on label-free quantification (LFQ) intensity.
ORGANISM(S): Homo sapiens (Human) 
2026-04-23 | PXD074538 | Pride
Lc-ms/ms Dia Humam Faps 
Transcriptomicsp62/SQSTM1 iCLIP in Human Huh-7 cells
These are the results of the iCLIP experiment for p62/SQSTM1 in Human Huh-7 cells treated with DMSO. We used iCLIP method to identify the RNA targets of p62 and nucleotide positions of the p62 interaction on RNA. We used 2 replicates and 2 different antibodies against endogenous p62 to enrich protei...
ORGANISM(S): Homo sapiens 
2018-03-31 | E-MTAB-4894 | biostudies-arrayexpress
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