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TranscriptomicsSIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing [CLIP-Seq]
SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-rRNA and promotes rRNA synthesis. Here we show that SIRT7 is also associated with sn...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-76578 | biostudies-arrayexpress
ProteomicsHPLC-MS datasets of the protein mix immunoprecipitated by SIRT7 antibody in HaCaT cells
We conducted HPLC-MS analysis of the protein mix immunoprecipitated by SIRT7 antibody under non-IR and 8 Gy X-ray irradiation to identify the interacting proteins of SIRT7 in HaCaT cells.
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033924 | Pride
Human Hplc-ms Sirt7 
TranscriptomicsSIRT7 suppresses tumorigenesis by attenuating MYC activity
SIRT7 is a member of the mammalian sirtuin family of NAD+ dependent deacylases, and interacts with RNA polymerase I and UBF to regulate rDNA transcription. Various studies in mammalian cells and human clinical data have linked SIRT7 to cancer. However studies differ as to whether SIRT7 is oncogen...
ORGANISM(S): Mus musculus 
2014-08-20 | E-GEOD-50076 | biostudies-arrayexpress
ProteomicsSIRT6 and SIRT7 binding proteome
To find the SIRT6 and SIRT7 binding proteins, we expressed V5-tagged SIRT6 and SIRT7 and pulled down this protein with anti-V5 agarose affinity gel. Sirtuins are a family of NAD-dependent deacetylases which deacetylate not only histones but also a wide range of target proteins. Sirtuins are conserve...
ORGANISM(S): Homo sapiens (Human) 
2014-04-28 | PXD000159 | Pride
Sirt7 Sirt6 Lc-ms/ms 
ProteomicsIdentification of auto mono-ADP-ribosylation sites on SIRT6 and SIRT7
The aim of this project was to identify the auto mono-ADP-ribosylation sites on SIRT6 and SIRT7 to study the effect of the point mutations S56A and N189A respectively on their ADP-ribosylation activity. In addition, the mono-ADP-ribosylation pattern of SIRT7 was obtained in cells under different str...
ORGANISM(S): Homo sapiens (Human) 
2021-04-19 | PXD018344 | Pride
Sirtuins  sirt7  adp-ribosylation  macroh2a  glucose starvation  chromatin  calorie restriction  aging  orbitrap lumos  orbitrap eclipse 
GenomicsSIRT7 safeguards genome stability and suppresses colorectal tumorigenesis
SIRT7 safeguards genome stability and suppresses colorectal tumorigenesis
PRJNA575347 | ENA
GenomicsSIRT7 counteracts mesenchymal stem cell senescence via stabilizing heterochromatin
SIRT7 counteracts mesenchymal stem cell senescence via stabilizing heterochromatin
PRJNA609761 | ENA
ProteomicsA SIRT7-dependent acetylation switch regulates early B-cell differentiation and lineage commitment through PAX5
B lymphopoiesis is a key developmental event orchestrated by a complex combinatorial action of lineage-specific transcription factors. In early B cell progenitors, lineage commitment is directly mediated by the master regulator PAX5, whose deficiency is commonly associated with B cell Acute Lymphobl...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-20 | PXD046457 | Pride
Sirtuins Sirt7 Acetylation Pax5 B cell progenitors Pre-b cell Hematopoiesis Immunoaffinity 
GenomicsRNASeq profiliting of spermatogonia from Wt and Sirt7-/- mice
RNASeq profiliting of spermatogonia from Wt and Sirt7-/- mice
PRJNA1379605 | ENA
GenomicsSIRT7 liver
SIRT7 liver
PRJNA896547 | ENA
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