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MetabolomicsDendrobium officinale Polysaccharide Ameliorates High-Fat Diet-Induced Hepatic Lipid Metabolic Disorder via the SIRT6/PGC-1α Signaling Axis
Aims: This study aims to explore the potential therapeutic effect of Dendrobium officinale polysaccharide (DOP) on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD), and to elucidate the underlying mechanism involving the SIRT6/PGC-1α signaling axis and the regulation of the g...
2026-05-25 | MTBLS14575 | MetaboLights
MetabolomicsLiver metabolomics in old liver-specific SIRT6 overexpressing mice
Not available
ORGANISM(S): Mus musculus 
ST001508 | MetabolomicsWorkbench
MetabolomicsHepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice
Not available
ORGANISM(S): Mus musculus 
ST001507 | MetabolomicsWorkbench
ProteomicsA rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in the regulation of aging and metabolism. Targeted sequencing identified a SIRT6 allele containing two linked substitutions (N308K/A313S) as enriched in Ashkenazi Jewis...
ORGANISM(S): Homo sapiens (Human) 
2022-10-21 | PXD035689 | Pride
Lmna Centenarian Longevity Sirt6 Adp-ribosylation Aging 
TranscriptomicsSIRT6 regulates glucose metabolism and glutamatergic synapse in the mouse retina
Microarray analysis on total retinal RNA from 15 day old Sirt6 wild-type (WT) and knock-out (KO) mice. The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod photoreceptors and downstream ON-bipolar neurons is a highl...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-56563 | biostudies-arrayexpress
TranscriptomicsSIRT6 and SIRT1 contribute to circadian gene expression
Comparison of the hepatic circadian transcriptomes reveals that SIRT6 and SIRT1 separately control transcriptional specificity, and therefore, define distinctly partitioned classes of circadian genes. Livers from WT and SIRT6 KO mice, and livers from WT and SIRT1 KO mice, were harvested over the cir...
ORGANISM(S): Mus musculus 
2014-08-05 | E-GEOD-57830 | biostudies-arrayexpress
ProteomicsSIRT6 and SIRT7 binding proteome
To find the SIRT6 and SIRT7 binding proteins, we expressed V5-tagged SIRT6 and SIRT7 and pulled down this protein with anti-V5 agarose affinity gel. Sirtuins are a family of NAD-dependent deacetylases which deacetylate not only histones but also a wide range of target proteins. Sirtuins are conserve...
ORGANISM(S): Homo sapiens (Human) 
2014-04-28 | PXD000159 | Pride
Sirt7 Sirt6 Lc-ms/ms 
TranscriptomicsSirt6 study
This SuperSeries is composed of the following subset Series: GSE13206: Human shSIRT6 TNF-alpha timecourse GSE13207: Mouse Sirt6-/- TNF-alpha timecourse GSE13208: Mouse Sirt6-/- tissues GSE13209: Mouse Sirt6-/- RelA+/- tissues Refer to individual Series
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13272 | biostudies-arrayexpress
TranscriptomicsMouse Sirt6-/- RelA+/- tissues
We harvested spleen tissue from Sirt6-/- or Sirt6-/- RelA+/- animals and then completed genome-wide microarray analysis. Total RNA was extracted with TRIzol (Invitrogen) and amplified with Amino Allyl MessageAmp II Amplification kit. Amplified age-matched wild-type tissues were used as reference RNA...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13209 | biostudies-arrayexpress
TranscriptomicsSirt6 transgene mice
The significant increase in the human life-span during the last century confronts us with great medical challenges. To answer them, one must understand and control the mechanisms that determine healthy ageing. The highly conserved sirtuin deacetylases were shown to regulate life-span in lower organi...
ORGANISM(S): Mus musculus 
2012-04-01 | E-MTAB-871 | biostudies-arrayexpress
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