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GenomicsThe DNA methylomes of a newborn and a centenarian
We have developed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and a centenarian to address the epigenetic drifts in human aging, which might be an alternative pathway to explain the age-associated alterations. In addition, we have analyzed the methylome of a middle-age donor (26 years). Ex...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-31263 | biostudies-arrayexpress
TranscriptomicsThe DNA Methylomes of a Newborn and a Centenarian
Examination of two DNA methylomes at the most extreme points of their lives to see differences that might contribute to explain the aged phenotype We have performed Whole Genome Bisulfite Sequencing (WGBS) and methylation array technology of newborn and a centenarian samples to address the Epigeneti...
ORGANISM(S): Homo sapiens 
2012-07-10 | E-GEOD-31438 | biostudies-arrayexpress
UnknownData quality in centenarian research: The proxy-centenarian relationship and item nonresponse in the SWISS100 study.
Not available
S-EPMC11771874 | biostudies-literature
ProteomicsEpigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant
Obesity is a major health burden. Adipogenesis, the proliferation and differentiation of pree-adipocytes in mature adipocytes, could be a potential therapeutic approach for obesity. Deficiency of SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD)+-dependent protein deac...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD051761 | Pride
Adipogenesis Epigenetics Obesity. Histones Sirt6 
GenomicNHLBI and NIA The New England Centenarian Study (NECS)

Supercentenarians (age 110+ years old) generally delay or escape age-related diseases and disability well beyond the age one hundred and this exceptional survival is likely to be influenced by a genetic predisposition that includes both common and rare genetic variants. In this report, we describ...

phs000451 | dbGaP
Methylation profilingThe DNA methylomes of a newborn and a centenarian
We have developed Whole Genome Bisulfite Sequencing (WGBS) of a newborn and a centenarian to address the epigenetic drifts in human aging, which might be an alternative pathway to explain the age-associated alterations. In addition, we have analyzed the methylome of a middle-age donor (26 years).
ORGANISM(S): Homo sapiens 
2012-06-13 | GSE31263 | GEO
TranscriptomicsDNA methylation differences between Newborns and Nonagenarians [PBMNC]
Human aging implies many phenotypic modifications and an increased susceptibility to many common diseases, phenomena that cannot be fully explained by the constrained genetic setting. An alternative pathway that could explain the age-associated alterations is epigenetic drifts. To address this issue...
ORGANISM(S): Homo sapiens 
2012-06-12 | E-GEOD-33233 | biostudies-arrayexpress
UnknownPurpose in Life Among Centenarian Offspring.
Not available
S-EPMC7179803 | biostudies-literature
UnknownEdentulousness and the Likelihood of Becoming a Centenarian: Longitudinal Observational Study.
Not available
S-EPMC11951808 | biostudies-literature
UnknownReduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.
Not available
S-EPMC6298187 | biostudies-literature
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