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MetabolomicsChronic inorganic nitrate supplementation does not improve metabolic health and worsens disease progression in mice with diet-induced obesity.
Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the Metabolic Syndrome (MetS), type-II diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric o...
2025-07-14 | MTBLS9526 | MetaboLights
TranscriptomicsInhibition of Peripheral Serotonin Activates Hepatic AMPK and Reduces Monocyte-Derived Liver Macrophages, Ameliorating Obesity-Associated Fibrosis
Monocyte-derived liver macrophages are critical in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, but their recruitment mechanisms remain unclear. Serotonin (5-hydroxytryptamine, 5HT) is a conserved monoamine synthesized by tryptophan hydroxylase (Tph...
ORGANISM(S): Mus musculus 
2025-10-30 | E-MTAB-15760 | biostudies-arrayexpress
ProteomicsColonic metaproteomic signatures of active bacteria and the host in obesity
Colonic metaproteomic signatures of active bacteria and the host in obesity
ORGANISM(S): Metaproteome 
2015-08-15 | MSV000079242 | MassIVE
ProteomicsOmega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice
Soybean oil consumption is increasing worldwide and parallels the rise in obesity. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance and fatty liver in mice. Here, we show that the genetically modified s...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-08 | MSV000081149 | MassIVE
TranscriptomicsDEPTOR cell-autonomously promotes adipogenesis and associates with obesity
An understanding of the mechanisms regulating white adipose tissue (WAT) formation is key for developing of new tools to treat obesity and its related diseases. Here, we identify DEPTOR as a positive regulator of adipogenesis whose expression is associated with obesity. In a polygenic mouse model of...
ORGANISM(S): Mus musculus 
2012-08-14 | E-GEOD-38321 | biostudies-arrayexpress
TranscriptomicsJuvenile obesity in Ossabaw swine produces artery-specific transcriptional changes
We adopted a transcriptome-wide microarray analysis approach to determine the extent to which vascular gene expression is altered as a result of juvenile obesity and identify obesity-responsive mRNAs. We examined transcriptional profiles in the left anterior descending coronary artery (LAD), perivas...
ORGANISM(S): Sus scrofa 
2013-05-29 | E-GEOD-41636 | biostudies-arrayexpress
TranscriptomicsAdipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity
This SuperSeries is composed of the following subset Series: GSE25401: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [gene expression] GSE25470: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [miRNA data] GSE25910: Adipose Tissue MicroRNAs as ...
ORGANISM(S): Homo sapiens 
2012-08-12 | E-GEOD-25402 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse strains A/J versus C57BL/6J during diet-induced obesity
The effects of high-fat (HF) feeding on the gene expression in the small intestine were examined using obesity-resistant A/J mice and obesity-sensitive C57BL/6J (B6) mice. Both strains of mice were maintained on low-fat (LF, 5% fat) or HF (30% fat) diets for two weeks. Oligonucleotide microarray and...
ORGANISM(S): Mus musculus 
2008-11-06 | E-GEOD-3433 | biostudies-arrayexpress
TranscriptomicsObesity-associated variants within FTO form long-range functional connections with IRX3
Genome-wide association studies in diverse populations have reproducibly associated variants within introns of FTO with increased risk for obesity and type-2 diabetes.While the molecular mechanisms linking these noncoding variants with obesity are not immediately obvious, subsequent studies in mice ...
ORGANISM(S): Danio rerio 
2014-02-24 | E-GEOD-52830 | biostudies-arrayexpress
TranscriptomicsGene transcription signature of obesity in breast cancer
Obesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted endocrine factors, insulin, and insulin-like growth factors (IGFs) that accelerate tumor cell proliferation and impair treatment response. We examined the effects of patie...
ORGANISM(S): Homo sapiens 
2011-07-17 | E-GEOD-24185 | biostudies-arrayexpress
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