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GenomicsGene expression in p62/SQSTM1-silenced A549 cells.
Gene expression in p62/SQSTM1-silenced A549 cells.
PRJNA860182 | ENA
Genomicsp62/SQSTM1 iCLIP in Human Huh-7 cells
p62/SQSTM1 iCLIP in Human Huh-7 cells
PRJEB19002 | ENA
ProteomicsHuman, melanoma, p62/SQSTM1, quantitative proteomics
p62/SQSTM1 was identified as a modulator of metastatic genes selectively enriched in melanoma in autophagy independent manner. iTRAQ quantitative proteomic approach was performed in melanoma cell lines (SK-Mel-103 and UACC-62) deficient for p62 to identify downstream effectors of p62. Similar studie...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006650 | Pride
Human Ap-ms P62/sqstm1 Melanoma cell lines Quantitative proteomics Lc-ms/ms 
ProteomicsThe autophagy receptor SQSTM1/p62 is a restriction factor of HCMV infection
Background: Intrinsic defence mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here we addressed the question how the autophagy receptor sequestome 1 (SQSTM1/p62, herein termed p62) interfered with human cytomegalovirus (HCMV) infection. (2) Meth...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus sp. 
2025-05-13 | PXD055196 | Pride
Human cytomegalovirus  autophagy receptor  sqstm1/p62  optineurin  host cell defence 
ProteomicsThe autophagy receptor SQSTM1/p62 is a restriction factor of HCMV infection
(1) Background: Intrinsic defence mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here we addressed the question how the autophagy receptor sequestome 1 (SQSTM1/p62, herein termed p62) interfered with human cytomegalovirus (HCMV) infection. (2) ...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2025-05-07 | PXD055194 | Pride
Human cytomegalovirus  autophagy receptor  sqstm1/p62  optineurin  host cell defence 
ProteomicsThe autophagy receptor SQSTM1/p62 is a restriction factor of HCMV infection
Background: Intrinsic defence mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here we addressed the question how the autophagy receptor sequestome 1 (SQSTM1/p62, herein termed p62) interfered with human cytomegalovirus (HCMV) infection. (2) Meth...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055195 | Pride
Human cytomegalovirus  autophagy receptor  sqstm1/p62  optineurin  host cell defence 
ProteomicsSQSTM1/p62-directed metabolic reprogramming is essential for normal neurodifferentiation
Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the ageing population, but their aetiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases, with known genetic cause, provides an opportunity to unde...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD006647 | Pride
Mitophagy Neurodifferentiation Hypoxia Mitochondria Oxidative stress Neuroepithelial-like stem cells P62 Sqstm1 Neuronal development 
Transcriptomicsp62/SQSTM1 iCLIP in Human Huh-7 cells
These are the results of the iCLIP experiment for p62/SQSTM1 in Human Huh-7 cells treated with DMSO. We used iCLIP method to identify the RNA targets of p62 and nucleotide positions of the p62 interaction on RNA. We used 2 replicates and 2 different antibodies against endogenous p62 to enrich protei...
ORGANISM(S): Homo sapiens 
2018-03-31 | E-MTAB-4894 | biostudies-arrayexpress
GenomicsCardiac p62/Sqstm1 maintains Nrf2 protein levels and protects from oxidative stress
Cardiac p62/Sqstm1 maintains Nrf2 protein levels and protects from oxidative stress
PRJNA802961 | ENA
TranscriptomicsGene expression in p62/SQSTM1-silenced A549 cells.
We used microarrays to detail the programme of gene expression in control or p62/SQSTM1-silenced A549 cells.
ORGANISM(S): Homo sapiens 
2022-07-21 | GSE208588 | GEO
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