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TranscriptomicsThe Role of SQSTM1 (P62) in Mitochondrial Function and Clearance in Human Cortical Neurons
We have assessed the importance of SQSTM1 in human induced pluripotent stem cell (iPSC)-derived cortical neurons with and without SQSTM1. By combining high-content imaging, RNA-Seq, and functional mitochondrial readouts, we showed that SQSTM1 depletion causes aberrations in mitochondrial gene expres...
ORGANISM(S): Homo sapiens 
2021-01-18 | E-MTAB-9383 | biostudies-arrayexpress
GenomicsGene expression in p62/SQSTM1-silenced A549 cells.
Gene expression in p62/SQSTM1-silenced A549 cells.
PRJNA860182 | ENA
TranscriptomicsTranscription profiling of human neuroblastoma cell line IMR-32 overexpressiong SQSTM1 and DPP3 to identify activators for the antioxidant response element
The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5’ flanking region of many phase II detoxification enzymes. Upregulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is largely unknown. By scr...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6451 | biostudies-arrayexpress
GenomicsThe Role of SQSTM1 (P62) in Mitochondrial Function and Clearance in Human Cortical Neurons
The Role of SQSTM1 (P62) in Mitochondrial Function and Clearance in Human Cortical Neurons
PRJEB39474 | ENA
Genomicsp62/SQSTM1 iCLIP in Human Huh-7 cells
p62/SQSTM1 iCLIP in Human Huh-7 cells
PRJEB19002 | ENA
ProteomicsProximity labeling reveals dynamic changes in the SQSTM1 protein network
Sequestosome1 (SQSTM1) is an autophagy receptor that mediates degradation of intracellular cargo, including protein aggregates, through multiple protein interactions. These interactions form the SQSTM1 protein network that are mediated by SQSTM1 functional interaction domains, which include LIR, PB1...
ORGANISM(S): Homo sapiens (Human) 
2024-08-06 | PXD047725 | Pride
Autophagy Turboid Proximity labeling Tau Protein aggregation P62 Sqstm1 Mapt 
ProteomicsThe auophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-11 | PXD012121 | Pride
Autophagy  autophagy receptors  cpda  glucocorticoids  inflammation  nfe2l2/nrf2  sqstm1/p62 
ProteomicsHuman, melanoma, p62/SQSTM1, quantitative proteomics
p62/SQSTM1 was identified as a modulator of metastatic genes selectively enriched in melanoma in autophagy independent manner. iTRAQ quantitative proteomic approach was performed in melanoma cell lines (SK-Mel-103 and UACC-62) deficient for p62 to identify downstream effectors of p62. Similar studie...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006650 | Pride
Human Ap-ms P62/sqstm1 Melanoma cell lines Quantitative proteomics Lc-ms/ms 
TranscriptomicsGene expression in p62/SQSTM1-silenced A549 cells.
We used microarrays to detail the programme of gene expression in control or p62/SQSTM1-silenced A549 cells.
ORGANISM(S): Homo sapiens 
2022-07-21 | GSE208588 | GEO
ProteomicsThe autophagy receptor SQSTM1/p62 is a restriction factor of HCMV infection
Background: Intrinsic defence mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here we addressed the question how the autophagy receptor sequestome 1 (SQSTM1/p62, herein termed p62) interfered with human cytomegalovirus (HCMV) infection. (2) Meth...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055195 | Pride
Human cytomegalovirus  autophagy receptor  sqstm1/p62  optineurin  host cell defence 
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