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TranscriptomicsRNAi knock down of the DNA-repair enzyme and transcriptional co-activator APE1 in human HeLa cells
Transcriptional profiling was done following APE1/Ref1 silencing using conditional gene expression knockdown by RNA interference (RNAi) technology in HeLa cell lines. APE1 is a DNA-repair enzyme and transcriptional co-activator. Knockdown leads to cell-growth arrest, apoptosis and impairment in the ...
ORGANISM(S): Homo sapiens 
2009-02-02 | E-MEXP-1315 | biostudies-arrayexpress
ProteomicsAPE1 (apurinic/apyrimidinic endonuclease 1): newly identified post-translational modifications (PTMs)
APE1 (apurinic/apyrimidinic endonuclease 1) is a multifunctional protein essential for both DNA base excision repair and redox signaling. However, its post-translational modifications (PTMs), which are key to modulating its cellular functions, remain largely uncharacterized due to their dynamic and ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD067266 | Pride
Ptms Ape1 Live-cell Lc-ms/ms 
ProteomicsAPE1 INTERACTOME - Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures
The present work aimed at defining the association of the APE1-protein-protein interactions network in modulating its role in tumor progression and chemoresistance through proteomic and bionformatic analyses
ORGANISM(S): Homo sapiens (Human) 
2020-01-16 | PXD013368 | Pride
Nlc/ms/ms Interactome 
ProteomicsAUF1 recognizes 8-oxo-guanosine embedded in DNA and stimulates APE1 endoribonuclease activity
The presence of rNMPs embedded in DNA represents a frequent genomic event able to destabilize the DNA backbone and to alter DNA replication and transcription. Usually, rNMPs are excised by RNase H2 and fully repaired by other enzymes belonging to the ribonucleotide excision repair pathway. The exist...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD027252 | Pride
Ape1 Dna-binding protein 
TranscriptomicsAPE1 knock-in
APE1/Ref-1 protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through its independent activity as a redox transcriptional co-activator. To dissect between redox- and DNA-repair-mediated effects, here we performed transcription profi...
ORGANISM(S): Homo sapiens 
2011-10-01 | E-MEXP-2941 | biostudies-arrayexpress
GenomicsAPE1 deficiency in mESC [CRISPR Screen]
APE1 deficiency in mESC [CRISPR Screen]
PRJNA1254497 | ENA
GenomicsAPE1 deficiency in mESC [RNA-Seq]
APE1 deficiency in mESC [RNA-Seq]
PRJNA1254499 | ENA
GenomicsTranscriptional regulation of APE1-redox Axis in Esophageal adenocarcinoma
Transcriptional regulation of APE1-redox Axis in Esophageal adenocarcinoma
PRJNA1507346 | ENA
ProteomicsAcetylation of p62 regulates base excision repair through interaction with APE1
p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD034899 | Pride
Sirt7 Ape1 P62 Base excision repair Acetylation Hmof 
ProteomicsAcetylation of p62 regulates base excision repair through interaction with APE1
p62, a well-known adaptor of autophagy, plays multiple functions in response to various stresses. Here, we report a function for p62 in base excision repair that is distinct from its known functions. Loss of p62 impairs BER capacity and increases the sensitivity of cancer cells to alkylating and oxi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD034901 | Pride
Sirt7 Ape1 P62 Base excision repair Acetylation Hmof 
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