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ProteomicsPurification of ubiquitylated proteins from HCT116 cells
By hyperosmotic stimuli, a slight increase in the level of ubiquitylated proteins was observed. So we tried to identify the di-Gly peptides.
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD016369 | Pride
Ubiquitylated proteins Lc-ms/ms 
ProteomicsA STUB1-CHIC2 complex decreases IL-27Rα expression on CD8+ T cells to restrain tumor immunity
CRISPR screens in CD8+ T cells have uncovered novel immunotherapy targets for cancer; however, these screens used activated CD8+ T cells, precluding identification of genes regulating CD8+ T cell priming in the tumor-draining lymph (tdLN). Here we present an 899-gene in vivo CRISPR screen in naive C...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-12 | PXD049402 | Pride
Tumor immunity Il27ra Crispr Stub1 Chic2 
ProteomicsUbiquitination-proteomics in mouse primary macrophages
To determine all ubiquitination modified proteins and corresponding ubiquitinated sites, we performed di-Gly LC/MS in mouse primary macrophages (MG132-treated).
ORGANISM(S): Mus Musculus 
PXD045946 |
ProteomicsdiGly ubiquitin remnant profiling upon TFEB overexpression
We performed proteomic analysis of di-Gly peptides to identify which proteins are ubiquitinated in cells overexpressing TFEB compared to non-expressing cells.
ORGANISM(S): Homo sapiens (Human) 
2025-11-18 | PXD065497 | Pride
Ubiquitin Digly Tfeb Hela 
UnknownCholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein.
Not available
S-EPMC10230161 | biostudies-literature
ProteomicsThe E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to infection
Phagocytosis is an essential process for the microbicidal function of professional phagocytes, in which phagosome maturation plays a critical role. Macrophage activation by interferons (IFN) increases their microbicidal activity, but delays phagosomal maturation. Here, we investigated the role of ub...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-20 | PXD026843 | Pride
Macrophage Phagosome Rnf115 Ubiquitin E3-ligase 
ProteomicsRsp5/Nedd4 is the major ubiquitin ligase that targets cytosolic misfolded proteins upon heat-stress
The heat-shock response is a complex cellular program that induces major changes in protein translation, folding and degradation to alleviate toxicity caused by protein misfolding. While heat-shock has been widely used to study proteostasis, it remained unclear how misfolded proteins are targeted fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-07-06 | PXD001214 | Pride
Rsp5 Heat-shock Cytosolic protein quality control 
ProteomicsEstablishment of a landscape of UPL5-ubiquitinated on multiple subcellular components of leaf senescence cell in Arabidopsis
Catabolism of macromolecules is a major event in senescent cells, especially involving proteolysis of organelles and abnormally aggregated proteins, the circulation of nutrients, and precise control of intracellular environmental balance. Proteasomes are distributed in the nucleus and cytoplasm; how...
ORGANISM(S): Arabidopsis Thaliana 
2022-04-30 | PXD033568 |
OtherConvergence of ubiquitylation and phosphorylation signaling in rapamycin-treated yeast cells.
Data from ProteomeXchange, PXD ID: PXD000554. Experiment: SILAC_SC_Rap048_2ndrep_SCX, file: folder summary. Published as part of Mol Cell Proteomics. 2014 Aug;13(8):1979-92 . From the Abstract: {{i}} ... Here, we used a mass-spectrometry-based proteomics approach for the parallel quantification of ...
ORGANISM(S): Yeast 
GPM32320003896 | GPMDB
Resource Reanalysis 
UnknownPharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.
Not available
S-EPMC7561209 | biostudies-literature
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