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ProteomicsUBIQUITIN LIGASE STUB1 DESTABILIZES IFNγ-RECEPTOR COMPLEX TO SUPPRESS TUMOR IFNγ SIGNALING
The cytokine IFNγ differentially impacts on tumors upon immune checkpoint blockade (ICB). Despite our understanding of downstream signaling events, less is known about 36 regulation of its receptor (IFNγ-R1). With an unbiased genome-wide CRISPR/Cas9 screen for critical regulators of IFNγ-R1 cell sur...
ORGANISM(S): Homo sapiens (Human) 
2022-03-07 | PXD030580 | Pride
Immune checkpoint blockade Ubiquitination Ifnγ Stub1 Melanoma 
ProteomicsA STUB1-CHIC2 complex decreases IL-27Rα expression on CD8+ T cells to restrain tumor immunity
CRISPR screens in CD8+ T cells have uncovered novel immunotherapy targets for cancer; however, these screens used activated CD8+ T cells, precluding identification of genes regulating CD8+ T cell priming in the tumor-draining lymph (tdLN). Here we present an 899-gene in vivo CRISPR screen in naive C...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-12 | PXD049402 | Pride
Tumor immunity Il27ra Crispr Stub1 Chic2 
ProteomicsArsenic Trioxide Acts as a Molecular Glue to Promote STUB1-Mediated NPM-ALK Degradation in ALK⁺ ALCL
The NPM-ALK fusion constitutively activates ALK tyrosine kinase, driving oncogenesis in anaplastic large cell lymphoma (ALCL). Although arsenic trioxide (ATO) exhibits therapeutic potential in NPM-ALK⁺ ALCL by inhibiting proliferation and inducing apoptosis, its molecular mechanism remains unclear. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD073992 | Pride
Deslanoside Ato Targeted protein degradation Npm-alk+ alcl Stub1 Combination therapy 
GenomicsSTUB1 is an intracellular checkpoint for interferon gamma sensing
STUB1 is an intracellular checkpoint for interferon gamma sensing
PRJNA854156 | ENA
ProteomicsSTUB1 is an intracellular checkpoint for interferon gamma sensing
Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms underlying ICB resistance. Results from a published CRISPR sc...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-18 | PXD035392 | Pride
Mouse melanoma cell lines 
GenomicsSTUB1 Regulates Epithelial Function Through Mediating the EDAR/ NF-κB Pathway
STUB1 Regulates Epithelial Function Through Mediating the EDAR/ NF-κB Pathway
PRJNA1178325 | ENA
GenomicsSTUB1 dampens IFNγ response in tumors by destabilizing the IFNγ receptor complex
STUB1 dampens IFNγ response in tumors by destabilizing the IFNγ receptor complex
PRJNA644914 | ENA
TranscriptomicsSTUB1 is an intracellular checkpoint for interferon gamma sensing
Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms underlying ICB resistance. Results from a published CRISPR sc...
ORGANISM(S): Mus musculus 
2022-06-30 | GSE207208 | GEO
ProteomicsArsenic Trioxide Acts as a Molecular Glue to Promote STUB1-Mediated NPM-ALK Degradation in ALK⁺ ALCL
The NPM-ALK fusion constitutively activates ALK tyrosine kinase, driving oncogenesis in anaplastic large cell lymphoma (ALCL). Although arsenic trioxide (ATO) exhibits therapeutic potential in NPM-ALK⁺ ALCL by inhibiting proliferation and inducing apoptosis, its molecular mechanism remains unclear. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD074054 | Pride
Karpas299 Ato Targeted protein degradation Npm-alk+ alcl 
ProteomicsA STUB1-CHIC2 complex decreases IL-27Rα expression on CD8+ T cells to restrain tumor immunity
CRISPR screens in CD8+ T cells have uncovered novel immunotherapy targets for cancer; however, these screens used activated CD8+ T cells, precluding identification of genes regulating CD8+ T cell priming in the tumor-draining lymph (tdLN). Here we present an 899-gene in vivo CRISPR screen in naive C...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-12 | PXD062475 | Pride
E3 ligase Cd8 t cells Tumor immunity 
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