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TranscriptomicsKnockdown of CUL3 and PTEN in A549 lung adenocarcinoma cells
Non-small cell lung cancers (NSCLCs) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent events in NSCLC, such as mutations in PTEN, EGFR, KRAS, and ALK, are only detected in, at most, 30% of patients. Thus, many unidentified low-penetrant events are causing a s...
ORGANISM(S): Homo sapiens 
2015-05-15 | E-GEOD-68869 | biostudies-arrayexpress
ProteomicsCullin 3 Mouse Brain TMT-based Proteomics Analysis
This project consists in 3 datasets: - Samples from adult mouse brains (Hippocampus, Cortex and Cerebellum): Cul3 +/- or +/+; 5 animals per condition. - Samples from embryonic mouse cortex: either Cul3 +/- or +/+ - Samples from embryonic mouse cortex: Cul3 fl/fl Emx-1-Cre ("hom"); Cul3 +/fl Emx1-Cre...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-26 | PXD017040 | Pride
Mouse brain cullin 3 cul3 autism cortex cerebellum hippocampus embryonic adult tmt dda high ph rp 
ProteomicsNovel KEAP1 activator targeting C151 enhances CUL3 binding and decreases NRF2
Novel KEAP1 activator targeting C151 enhances CUL3 binding and decreases NRF2
ORGANISM(S): Homo sapiens (Human) 
2025-12-10 | PXD056257 | Pride
Nrf2 Keap1 Cul3 
GenomicsGenome-wide screens implicate loss of cullin ring ligase 3 in persistent proliferation and genome instability in TP53 deficient cells
CUL3-mRNASeq
PRJEB36947 | ENA
ProteomicsRNA Pol II IP-MS and GFP-CUL3 IP-MS by DIA
DIA MS dataset for RNA Polymerase II (Pol II) or GFP-CUL3 co-immunoprecipitants prepared from human DLD-1 SPT5-AID cells treated with +/- NVP-2 +/- auxin (for Pol II IP) or +/- auxin (GFP IP).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-26 | MSV000096543 | MassIVE
GenomicsBulk RNA sequencing of E14.5 embryonic hearts from cardiomyocyte-specific Cul3 conditional-knockout and control mice
Bulk RNA sequencing of E14.5 embryonic hearts from cardiomyocyte-specific Cul3 conditional-knockout and control mice
PRJNA1516559 | ENA
UnknownConstitutive turnover of cyclin E by Cul3 maintains quiescence.
Not available
S-EPMC1899986 | biostudies-literature
TranscriptomicsKnockdown of CUL3 and PTEN in A549 lung adenocarcinoma cells
Non-small cell lung cancers (NSCLCs) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent events in NSCLC, such as mutations in PTEN, EGFR, KRAS, and ALK, are only detected in, at most, 30% of patients. Thus, many unidentified low-penetrant events are causing a signi...
ORGANISM(S): Homo sapiens 
2015-05-15 | GSE68869 | GEO
TranscriptomicsGene expression changes in CD4+ thymocytes upon removal of Cullin3
We report gene expression changes in Cul3 deficient thymic CD4+ T cells We used microarrays to detail the global programme of gene expression changes upon removal of Cul3 during thymic development CD25-, CD1dPBS57-, gdTCR - CD4+ Single positive cells from thymocytes of CD4Cre-Cul3fl/fl (LM) and CD4 ...
ORGANISM(S): Mus musculus 
2014-04-05 | E-GEOD-56514 | biostudies-arrayexpress
UnknownDisruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis.
Not available
S-EPMC6418206 | biostudies-literature
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