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MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4933 | MetaboLights
ProteomicsA strategy to characterize the global histone PTM landscape within tissues of non-model organisms
Histone post-translational modifications (PTMs) are epigenetic marks that play a critical role in the expression and maintenance of DNA, but they remain largely uninvestigated in non-model organisms due to technical challenges. To begin alleviating this issue, we developed a workflow for histone PTM...
ORGANISM(S): Oreochromis Mossambicus 
2024-02-29 | PXD040536 | panorama
ProteomicsIdentification of ubiquitination sites of purified histone H3
Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive. When compared with their differentiated counterparts, immortal human embryonic stem cells (hESCs) have a unique chr...
ORGANISM(S): Homo sapiens (Human) 
2020-06-01 | PXD018621 | Pride
Epigenetics Ubiquitination Histone h3 
TranscriptomicsDeep sequencing shows multiple oligouridylations are required for 3' to 5' degradation of histone mRNAs on polyribosomes
We developed a customized RNA-Seq strategy to identify the 3' termini of degradation intermediates of histone mRNAs. Using this strategy, we identified two types of oligouridylated degradation intermediates: RNAs ending at different sites of the 3' side of the stemloop that resulted from initial deg...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-54922 | biostudies-arrayexpress
ProteomicsASB9 promotes ubiquitin-mediated degradation of TNP2 to facilitate histone-to-protamine transition in humans and mice
During spermiogenesis, nuclear remodeling occurs where histones are initially replaced by transition proteins (TNPs) and subsequently by protamines, a process essential for sperm maturation. Although the degradation of histones and TNPs is thought to be essential for sperm nuclear remodeling, the un...
ORGANISM(S): Mus Musculus 
2025-11-19 | PXD070974 |
ProteomicsLoss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma
We identified proteins that interact with FBXO45 and UPF1 through mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-10-29 | PXD057326 |
ProteomicsFunction of the histone N-terminal acetyltransferase Naa40 in DNA damage response
N-alpha-acetyltransferase 40 (NAA40) catalyzes acetylation on the N-terminal tip of histones H4 (N-acH4) and H2A (N-acH2A) harboring the Ser(1)-Gly(2)-Arg(3)-Gly(4) recognition sequence. In addition to the well-known role of N-terminal acetylation in protein degradation and stability, recent studies...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD050981 | Pride
Histone post-translational modifications Histone n-terminal acetylation 
ProteomicsRapid degradation of Histone Deacetylase 1 (HDAC1) reveals essential roles in both gene repression and active transcription
Histone Deacetylase 1 (HDAC1) removes acetyl groups from lysine residues on the core histones, balancing histone acetyltransferase (HAT) activity. Despite this apparent repressive function, suppression of HDAC activity causes both up and downregulation of gene expression. Here we exploit the degrada...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-27 | PXD053032 | Pride
Hdac1 Histone Acetylation 
Transcriptomics5-azacytidine treatment reorganizes genomic histone modification patterns
Methylation of DNA in combination with histone modifications establishes an epigenetic code that ensures the proper control of gene expression. Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a ...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-20598 | biostudies-arrayexpress
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