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ProteomicsComparison of in-gel digestion methods for histone PTM analysis
In order to optimize the histone digestion procedure for low-abundance clinical samples, we compared different in-gel digestion protocols. Histones are usually digested in-gel using “Arg-C-like” strategies, which involve chemical acylation of lysines followed by trypsin digestion (17). Acylated lysi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD024745 | Pride
Epigenetics Histone post-translationa modification 
ProteomicsHistone PTM analysis in breast cancer cells treated with methyltransferase inhibitors
Histone PTM analysis were analyzed in breast cancer cells treated with methyltransferase inhibitors.
ORGANISM(S): Homo sapiens (Human) 
2025-08-01 | PXD064421 | Pride
Histone post-translationa modifications Methyltransferase inhibitors 
ProteomicsMammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression
Histone acetylation is widely assumed to directly instruct gene activation. Among acetylated residues, H4K16ac is one of the most abundant modifications, conserved across all eukaryotes. Here we analyzed histone PTM profiles in MSL KO and HDAC inhibitor-treated cells.
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD066155 | Pride
Histone post translationa modification H4k16ac 
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