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MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
ProteomicsQuantitative histone mass spectrometry identifies elevated histone H3 lysine 27 trimethylation in melanoma
Normal cell growth is characterized by a regulated epigenetic program that drives cellular activities such as gene transcription, DNA replication and DNA damage repair. Perturbation of this epigenetic program can lead to events such as mis-regulation of gene transcription and diseases such as cancer...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079979 | MassIVE
GenomicsIdentification of transcription factor Srf binding sites and histone 3 actetylated regions in mouse cardiomyocytes
We investigated the cardiac transcription network driven by the DNA-binding key factor Srf in combination with epigenetic marks of histone 3 acetylation (H3ac). Srf has been shown to play a key role in cardiac cell growth and muscle gene regulation. However, we still have limited understanding of th...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-19065 | biostudies-arrayexpress
ProteomicsNucleosome binding by the pioneer transcription factor OCT4
The nucleosome is a fundamental unit of chromatin in eukaryotes, and generally prevents the binding of transcription factors to genomic DNA. Pioneer transcription factors overcome the nucleosome barrier, and bind their target DNA sequences in chromatin. OCT4 is a representative pioneer transcription...
ORGANISM(S): Homo Sapiens (human) 
2020-05-13 | PXD019160 | JPOST Repository
GenomicsGenome-wide analysis of histone modifications in human endometrial stromal cells [ChIP-Seq]
Dramatic changes of gene expressions are known to occur in human endometrial stromal cells (ESC) during decidualization. The changes in gene expression are associated with changes of chromatin structure, which are regulated by epigenetic mechanisms such as histone modifications. Here, we investiga...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-57007 | biostudies-arrayexpress
ModelsKoster1988_Histone_Expression
This model is described in the article: Kinetics of histone gene expression during early development of Xenopus laevis. Koster JG, Destrée OH and Westerhoff HV. J Theor Biol. 1988 Nov 21;135(2):139-67. PMID: 3267765 Abstract: ...
2005-01-01 | MODEL5954483266 | BioModels
TranscriptomicsHistone H1 binding is restricted by histone variant H3.3 (DamID)
Linker histones are involved in the formation of higher-order chromatin structure. Although linker histones have been implicated in the regulation of specific genes, it still remains unclear what their principal binding determinants are and how their repressive function in vitro can be reconciled wi...
ORGANISM(S): Drosophila melanogaster 
2010-06-21 | E-GEOD-16883 | biostudies-arrayexpress
TranscriptomicsSpt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast [RNA-seq]
Spt6 is a highly conserved histone chaperone that interacts directly with both RNA polymerase II and histones to regulate gene expression. To gain a comprehensive understanding of the requirements for this critical factor, we have performed genome-wide analyses of transcription, chromatin structure...
ORGANISM(S): Schizosaccharomyces pombe 
2013-10-09 | E-GEOD-49573 | biostudies-arrayexpress
TranscriptomicsA Basic Domain in the Histone H2B N-terminal Tail is Important for Nucleosome Assembly by FACT
Nucleosome assembly in vivo requires assembly factors, such as histone chaperones, to bind to histones and mediate their deposition onto DNA. In yeast, the essential histone chaperone FACT (FAcilitates Chromatin Transcription) functions in nucleosome assembly and H2A-H2B deposition during transcript...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-10 | E-GEOD-80831 | biostudies-arrayexpress
ProteomicsForebrain Hindbrain histone H4 Mus musculus P25 P47
Quantitative top down analysis of histone H4 proteoforms in the mouse forebrain and hindbrain at 25 and 47 days of age.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000090249 | MassIVE
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