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ProteomicsARIH2 is a novel Vif-dependent regulator of CUL5-mediated APOBEC3G degradation in HIV infection
Discovery of novel host-virus interactions leads to a better understanding of mechanisms underlying infection and points to potential therapeutic targets at the interface between virus and host proteins. Recently, global, virus-host interaction networks have been mapped using affinity purification-m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-29 | MSV000084855 | MassIVE
ProteomicsComparative analysis of differential cellular genome and proteome regulation by HIV-1 and HIV-2 pseudovirions in the early phase of infection
Beside the similar structure and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking difference exist between the in terms of replication dynamics and clinical manifestation of infection. Although pathomechanism of HIV-1 infection well characterized, relat...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Human Immunodeficiency Virus 2 (ncbitaxon:11709) Human Immunodeficiency Virus 1 (ncbitaxon:11676) 
2023-08-03 | MSV000092581 | MassIVE
TranscriptomicsNext-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection
HIV infection of CD4 T cells induces a range of host transcriptional changes in mRNAs as well as microRNAs that may coordinate changes in mRNAs. We applied next-generation sequencing, analyzing the small RNA fraction of HIV-infected cells at 5, 12, and 24 h postinfection (RNA-Seq).
ORGANISM(S): Homo sapiens 
2014-05-17 | E-GEOD-57763 | biostudies-arrayexpress
TranscriptomicsComparative analysis of genomic features of human HIV-1 infection and primate models of SIV infection
High levels of HIV-1 replication during the chronic phase of infection are usually associated with rapid disease progression (RP). However, a minority of HIV-infected individuals remain asymptomatic and show persistently high CD4+ T cell counts despite high viremia for many years (viremic non progre...
ORGANISM(S): Homo sapiens 
2011-06-03 | E-GEOD-28128 | biostudies-arrayexpress
MetabolomicsAltered milk tryptophan and tryptophan metabolites and health of children born to women with HIV (ZEBS study milk assays).

Children born to women with HIV (WWH) suffer increased morbidity and, in low-income settings, have two to three times the mortality of infants born to women without HIV. The basis for this increase remains elusive. In low-income settings, breastfeeding is recommended because health benefits outwe...

2025-08-26 | MTBLS2307 | MetaboLights
MetabolomicsAltered milk tryptophan and tryptophan metabolites and health of children born to women with HIV (Haiti study assays).

Children born to women with HIV (WWH) suffer increased morbidity and, in low-income settings, have two to three times the mortality of infants born to women without HIV. The basis for this increase remains elusive. In low-income settings, breastfeeding is recommended because health benefits outwe...

2025-08-26 | MTBLS2573 | MetaboLights
TranscriptomicsTranscription profiling of human CD4+/CD8+ T cells obtained from HIV patients at various stages of disease vs. uninfected individuals reveals HIV infection induces a persistent T cell transcriptional profile
We examined the gene expression profiles in ex vivo human CD4+ and CD8+ T cells from untreated HIV-infected individuals at different clinical stages and rates of disease progression. Profiles of pure CD4+ and CD8+ T cells subsets from HIV-infected nonprogressors who controlled viremia were indisting...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-6740 | biostudies-arrayexpress
TranscriptomicsDifferential expression associated with GB virus C in HCV/HIV co-infection
The aim of this study was to identify differential gene and protein expression associated with GBV-C that may be of importance in reduction of HCV-related liver disease. GB virus C (GBV-C) infection leads to improved outcomes in human immunodeficiency virus (HIV) infection. Furthermore, GBV-C has be...
ORGANISM(S): Homo sapiens 
2011-05-10 | E-GEOD-16593 | biostudies-arrayexpress
TranscriptomicsHuman Immunodeficiency Virus Tat Directly Interacts with a Specific Set of Cellular RNAs
We have used RNA immunoprecipitation to identify the set of mRNAs that HIV-1 Tat interacts with in T-cells. We have also performed measurements of relative RNA abundance to determine if Tat binding is associated with an increase in RNA abundance in Tat-expressing T-cells and during HIV infection of ...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-MEXP-3199 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of human naive CD4 T cells identifies miR-34c-5p as a novel regulator of T cell activation and HIV replication
Cell activation is a vital step for T cell memory/effector differentiation as well as for productive HIV infection. To identify novel regulators of this process, we used next generation sequencing to profile changes in microRNA expression occurring in purified human naive CD4 T cells in response to ...
ORGANISM(S): Homo sapiens 
2016-12-21 | E-MTAB-4214 | biostudies-arrayexpress
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