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TranscriptomicsInduction of IL-17+ T-cells by HIV-Tat protein is mediated via Vascular Endothelial Growth Factor Receptor-2
Anti-retroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection from a fatal illness to a chronic condition by controlling viral replication and restoring immune function. However, chronic T-cell activation can be observed in 20-35% of individuals on ART, resulting in an i...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-GEOD-44460 | biostudies-arrayexpress
TranscriptomicsHIV-1 Tat protein promotes neuronal dysfunction through disruption of microRNAs.
Over the last decade, small noncoding RNA molecules such as microRNAs (miRNAs) have emerged as critical regulators in the expression and function of eukaryotic genomes. It has been suggested that viral infections and neurological disease outcome may also be shaped by the influence of small RNAs. Thi...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44265 | biostudies-arrayexpress
TranscriptomicsTat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNAs by HIV-1
Herein expression trends of host miRNA were measured in CEMx174 lymphocytes infected with HIV-1NL4-3 or derivative strains deficient in Tat RSS activity (RSS) or vif-/vpr (VV), or unexposed to virus. As expected from previous studies, miRNA trends were different in naive and HIV-1 infected cells. ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-21892 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of HIV-1 Tat-induced dysregulation in SH-SY5Y neuroblastoma cells
Despite affecting up to 70% of HIV+ patients and being the leading cause of dementia in patients under 40 years, the molecular mechanisms involved in the onset of HAND are not well understood. To address this, we performed SILAC-based quantitative proteomic analysis on HIV-Tat treated SH-SY5Y neurob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-03-18 | MSV000083590 | MassIVE
GenomicsGenome-wide binding map of the HIV Tat protein to the human genome (ChIP-Seq)
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells (Jurkat-Tat cells) using chromatin immunopreci...
ORGANISM(S): Homo sapiens 
2011-11-06 | E-GEOD-30738 | biostudies-arrayexpress
TranscriptomicsHuman Immunodeficiency Virus Tat Directly Interacts with a Specific Set of Cellular RNAs
We have used RNA immunoprecipitation to identify the set of mRNAs that HIV-1 Tat interacts with in T-cells. We have also performed measurements of relative RNA abundance to determine if Tat binding is associated with an increase in RNA abundance in Tat-expressing T-cells and during HIV infection of ...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-MEXP-3199 | biostudies-arrayexpress
TranscriptomicsChIP-chip from KG-1 cells with HIV Tat
HIV-1 Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon-stimulated genes (ISGs) in the absence of interferons (IFNs). We investigated the genome-wide Tat association with cellular promoters in immature den...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-42191 | biostudies-arrayexpress
TranscriptomicsGene target specificity of the Super Elongation Complex (SEC) family: How HIV-1 Tat employs selected SEC members to activate viral transcription
The AF4/FMR2 proteins AFF1 and AFF4 act as a scaffold to assemble the Super Elongation Complex (SEC) that strongly activates transcriptional elongation of HIV-1 and cellular genes. Although they can dimerize, it is unclear whether the dimers exist and function within a SEC in vivo. Furthermore, it i...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-69021 | biostudies-arrayexpress
ProteomicsIdentification of host factors interacting with HIV-1 Tat
The promiscuous biotin ligase TurboID was fused to Tat for precise and temporal biotinylation of surrounding proteins, which could be enriched by streptavidin and identified by mass spectrometry.
ORGANISM(S): Homo Sapiens 
2025-01-03 | PXD059409 |
TranscriptomicsHIV-1 TAT SUPPRESSES THE TCR/CD3 MACHINERY IN HUMAN CD4+ T CELLS [Tat]
Our previous work demonstrated that HIV-1 infection progressively reduces TCR/CD3 expression due to a defect in CD3g gene transcripts. We further found that knocking down expression of the viral tat and/or nef genes was correlated with CD3g transcript and TCR/CD3 surface receptor levels on HIV-1 inf...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-33705 | biostudies-arrayexpress
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