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ProteomicsMachine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome
HLA-DQ molecules can be formed as both cis and trans variants. So far, the progress for predicting HLA-DQ antigen presentation has been limited. In addition, the contribution of trans-only variants in shaping the HLA-DQ immunopeptidome remains largely unresolved. Here, we address these issues by int...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040860 | Pride
Machine learning Immunopeptidome Hla-dq 
GenomicsHLA-DQ?1 insertion
Achalasia cases & controls
EGAD00010000858 | EGA
UnknownHLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes.
Not available
S-EPMC8782272 | biostudies-literature
UnknownHLA-DQ heterodimers in hematopoietic cell transplantation.
Not available
S-EPMC9121842 | biostudies-literature
UnknownHLA-DQ Mismatching and Kidney Transplant Outcomes.
Not available
S-EPMC5968890 | biostudies-literature
UnknownQualitative, rather than quantitative, differences between HLA-DQ alleles affect HLA-DQ immunogenicity in organ transplantation.
Not available
S-EPMC11003724 | biostudies-literature
ProteomicsDifferent Binding Motifs of the Celiac Disease Associated HLA Molecules DQ2.5, DQ2.2 and DQ7.5 Revealed by Relative Quantitative Proteomics of Endogenous Peptide Repertoires
In this study relative quantitative analysis of endogenous peptides by mass spectrometry combined with neural network analysis have been used to address why the alpha- or beta-chain sharing human leukocyte antigen (HLA)-DQ molecules DQ2.5, DQ2.2 and DQ7.5 display different risks for celiac disease. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080859 | MassIVE
GenomicsExpression levels of HLA-DRB and HLA-DQ are associated with MHC Class II haplotypes in healthy individuals and rheumatoid arthritis patients
Expression levels of HLA-DRB and HLA-DQ are associated with MHC Class II haplotypes in healthy individuals and rheumatoid arthritis patients
PRJNA686938 | ENA
TranscriptomicsExpression levels of HLA-DRB and HLA-DQ are associated with MHC Class II haplotypes in healthy individuals and rheumatoid arthritis patients
HLA-DRB1 alleles have been associated with several autoimmune diseases. In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), HLA-DRB1 shared epitope (SE) alleles are the major genetic risk factors. In order to investigate whether expression of different alleles of...
ORGANISM(S): Homo sapiens 
2020-12-22 | GSE163605 | GEO
UnknownHLA-DP, HLA-DQ, and HLA-DR have different requirements for invariant chain and HLA-DM.
Not available
S-EPMC3003381 | biostudies-literature
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