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ProteomicsIdentification of In Vivo HLA-DR-Presented Self-Peptides (T Cell Epitopes) in Synovial Tissue, Synovial Fluid and Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis
HLA-DR molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory arthritides, including in rheumatoid arthritis (RA) and Lyme arthritis (LA). In the current study, we identified HLA-DR-presented self-peptides (T cell epitopes) in ST, synovial f...
ORGANISM(S): Homo sapiens (Human) 
2016-10-13 | PXD003051 | Pride
Synovial tissue Synovial fluid Human Peripheral blood Lc-ms/ms 
ProteomicsHLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis
Autoimmune diseases are often associated with HLA molecules. Multiple sclerosis (MS) is a prototypical example with the HLA-DR15 haplotype as strongest genetic factor. How it contributes to MS is not clear, but key to understand this and other autoimmune diseases. Autoreactive CD4+ T cells and proin...
ORGANISM(S): Homo sapiens (Human) 
2020-10-22 | PXD015249 | Pride
Multiple sclerosis Hla cross-restriction Immunopeptidome B cells Hla-dr-derived self-peptides Cross-reactivity Hla-dr15 molecules Autoreactive cd4+ t cells 
UnknownNitration of the pollen allergen bet v 1.0101 enhances the presentation of bet v 1-derived peptides by HLA-DR on human dendritic cells.
Not available
S-EPMC3279363 | biostudies-literature
UnknownImmunogenic HLA-DR-Presented Self-Peptides Identified Directly from Clinical Samples of Synovial Tissue, Synovial Fluid, or Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis.
Not available
S-EPMC5766322 | biostudies-literature
ProteomicsImmunopeptidomics analysis of human atherosclerosis plaques identifies antigenic drivers of atherosclerosis
Atherosclerosis has an auto-immune component driven by self-reactive T and B cells. Identifying their antigenic drivers may lead to new diagnosis and treatment approaches. Here, we aim to identify immunogenic T cell epitopes derived from atherosclerosis-relevant proteins such as ApoB100 by studying ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD068446 | Pride
Immunopeptidomics Pbmcs Apob100 Antigen-specific t cells 
UnknownBorrelia burgdorferi-Induced Changes in the Class II Self-Immunopeptidome Displayed on HLA-DR Molecules Expressed by Dendritic Cells.
Not available
S-EPMC7524959 | biostudies-literature
UnknownHLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.
Not available
S-EPMC7707104 | biostudies-literature
UnknownDesigning a SARS-CoV-2 T-Cell-Inducing Vaccine for High-Risk Patient Groups.
Not available
S-EPMC8146137 | biostudies-literature
UnknownPresence of T cells directed against CD20-derived peptides in healthy individuals and lymphoma patients.
Not available
S-EPMC6805815 | biostudies-literature
UnknownHuman leukocyte antigen HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis.
Not available
S-EPMC10690166 | biostudies-literature
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