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ProteomicsDeep motif deconvolution of HLA-II peptidomes
CD4 T cells are key for priming and regulating immune recognition of infected and cancer cells, but predictions of class II epitopes have limited accuracy. We profiled over 100’000 HLA-II ligands by Mass Spectrometry and developed a novel motif deconvolution algorithm to analyze these data. Our work...
ORGANISM(S): Homo sapiens (Human) 
2019-10-16 | PXD012308 | Pride
Immunopeptidomics Ligand predictions Mass spectrometry Hla class ii Neoantigens 
ProteomicsCIITA-transduced glioblastoma cells uncover a rich repertoire of clinically relevant tumor-associated HLA-II antigens
CD4+ T cell responses are crucial for inducing and maintaining effective anti-cancer immunity, and the identification of HLA-II cancer-specific epitopes is key to the development of potent cancer immunotherapies. In many tumor types, and especially in glioblastoma (GBM), HLA-II complexes are hardly ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD020079 | Pride
Glioblastoma Immunopeptidomics Antigen presentation Ciita 
ProteomicsHLA-I and HLA-II peptidomes for NESSIE
MS data of HLA class I and HLA class II ligandome of human colon tissue and LCLs
ORGANISM(S): Homo Sapiens (human) 
2024-08-08 | PXD047303 | JPOST Repository
ProteomicsHLA class II ligandome of colon cancer tissues for neoantigen identification
MS data of HLA class II ligandome of human colon cancer tissues
ORGANISM(S): Homo Sapiens (human) 
2024-09-25 | PXD054060 | JPOST Repository
ProteomicsDeep motif deconvolution of HLA-II peptidomes
CD4 T cells are key for priming and regulating immune recognition of infected and cancer cells, but predictions of class II epitopes have limited accuracy. We profiled over 100’000 HLA-II ligands by Mass Spectrometry and developed a novel motif deconvolution algorithm to analyze these data. Our work...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-18 | MSV000096130 | MassIVE
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD025499 | Pride
Sars-cov-2 Immunopeptidomics Hla-peptidomics 
GenomicsFull-length HLA class II sequences
Full-length HLA class II sequences
PRJEB42469 | ENA
GenomicsHLA Class I/II submissions 240607
HLA class I/II submissions 240607
PRJEB76430 | ENA
GenomicsHLA class II subs
HLA class II full-length submissions 30/08/2022
PRJEB55642 | ENA
ProteomicsDefining HLA-II ligand processing and binding rules with mass spectrometry enhances cancer epitope prediction
Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and control tumor growth. However, it remains difficult to predict the antigens that will be presented by human leukocyte antigen class II molecules (HLA-II) - hindering efforts to optimally target them therapeutically...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-18 | MSV000083991 | MassIVE
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