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ProteomicsB cell Lymphomas present Immunoglobulin Neoantigens
Immunoglobulin gene rearrangement and somatic hypermutation have the potential to create neoantigens in non-Hodgkin B cell lymphoma. However, the presentation of these putative immunoglobulin neoantigens by B cell lymphomas has not been proven. We used MHC immunoprecipitation followed by liquid chr...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010808 | Pride
Lymphoma Neoantigens Mhc Orbitrap 
ProteomicsExpanding the repertoire of chemically induced covalent neoantigens
The ubiquitin-proteasome system (UPS) generates peptide fragments that are displayed on class I major histocompatibility complex (MHC-I) molecules. Hapten-modified peptides, which are derived from proteins covalently modified by exogenous small molecules, have long been proposed as a mechanism for i...
ORGANISM(S): Homo sapiens (Human) 
2026-07-08 | PXD077352 | Pride
Immunopeptidomics Covalent neoantigens Mhc-i 
ProteomicsImmunopeptidomics guided identification of neoantigens in non-small cell lung cancer
Discovery of tumour specific peptides (neoantigens) generating target specific personalised T cell therapies is difficult because of the complex relationship between genetic mutations and neoantigen presentation. Studies predicting neoantigens have a 5% success rate, and direct observations of neoan...
ORGANISM(S): Homo sapiens (Human) 
2026-07-03 | PXD028990 | Pride
Cancer Hla Lung Neoantigen Peptidome 
ProteomicsAcute lymphoblastic leukemia in children produces endogenous T-cells targeting tumor associated antigens and neoantigens in peripheral blood
In this study we investigated the presence of endogenous T-cells recognizing private tumor-associated antigens and predicted neoantigens. To this end, HLA-I and HLA-II restricted tumor associated antigens (TAAs) and neoantigens were respectively identified and predicted. Of interest, circulating T-c...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD061914 | Pride
Human Pediatric leukemia Mass spectrometry Antigen discovery 
GenomicsNanopore sequencing combining AlphaFold2 identifies alternative splicing derived putative neoantigens in uveal melanoma
Nanopore sequencing combining AlphaFold2 identifies alternative splicing derived putative neoantigens in uveal melanoma
PRJNA851027 | ENA
GenomicsSystematic identification of recurrent immunogenic neoantigens in treatment-resistant tumors
Recurrent neoantigens in treatment-resistant tumors
PRJEB79570 | ENA
ProteomicsIdentification of neoantigens in oesophageal adenocarcinoma
We present data from tissues of seven oesophageal adenocarcinomas of CD4 and CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound peptides.This dataset forms part of the publication:Nicholas, B., Bailey, A., McCann, K.J., Wood, O., Walke...
ORGANISM(S): Homo sapiens (Human) 
2022-09-27 | PXD031108 | Pride
Human Oesophageal adenocarcinoma Immunopeptidome Hla 
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in hu...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD004746 | Pride
Human Mhc Mantle cell lymphoma Antigen presentation Ltq orbitrap elite 
ProteomicsAntigen Presentation Profiling Reveals T-cell Recognition of Lymphoma Immunoglobulin Neoantigens
Cancer somatic mutations can generate neoantigens that distinguish malignant from normal cells. Such neoantigens have been implicated in response to immunotherapies including immune checkpoint blockade, yet their identification and validation remains challenging. Here we discover neoantigens in huma...
ORGANISM(S): Homo sapiens (Human) 
2017-03-27 | PXD005704 | Pride
Human Antigen presentation Ltq orbitrap elite Mhc class i 
GenomicsA New Pipeline to Predict and Confirm Tumor Neoantigens Predicts Better Response to Checkpoint Blockade
A New Pipeline to Predict and Confirm Tumor Neoantigens Predicts Better Response to Checkpoint Blockade
PRJNA671267 | ENA
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