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TranscriptomicsTranscription profiling by array of human mammary epithelial cells (HMEC) stimulated with TNF vs. controls reveals TNF induces distinct expression programs
HMEC cultures were left untreated or stimulated for 5h with 2 ng/ml TNF. Comparison of the gene expression profiles revealed the TNF-mediated gene expression changes.
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-2638 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of the immortalized human endothelial cell lines HMEC-1 and TIME
The distinction between lymphatic and blood vessels is biologically fundamental. Two immortalized cell lines, which have been widely used as models for endothelial cells of blood vascular origin, are the human microvascular endothelial cell line-1 (HMEC-1) and the telomerase-immortalized microvascul...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-GEOD-42216 | biostudies-arrayexpress
TranscriptomicsExpression data of pre-stasis cultured HMEC
We have generated a large collection of normal human mammary epithelial cell strains from women aged 16 to 91 years, derived from primary tissues, to enable functional and molecular interrogation of aging. We demonstrate in finite-lifespan cultured and uncultured epithelial cells that aging is assoc...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37485 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human mono or co-cultured HMEC-1 and HK-2 cells to identify the influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells
The effect of the presence of HMEC-1 cells on HK-2 cell gene expression was investigated. Cells were cultured in mono or co-culture on opposite sides of aluminium oxide filters, 0.2 ?µM pore size. These conditions provide a close proximity but not direct contact. RNA from HK-2 cells was assayed with...
ORGANISM(S): Homo sapiens 
2008-02-05 | E-MEXP-1178 | biostudies-arrayexpress
TranscriptomicsDistinctions between the stasis and telomere attrition senescence barriers in cultured human mammary epithelial cells
Molecular distinctions between the stasis and telomere attrition senescence barriers in cultured human mammary epithelial cells Normal human epithelial cells in culture have generally shown a limited proliferative potential of ~10-40 population doublings before encountering a stress-associated sene...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-16058 | biostudies-arrayexpress
TranscriptomicsHistone H3 acetylation of miRNA genes in HMEC and HMF
Normal cell type specific histone H3 acetylation of miRNA genes. HMEC and HMF represent two distinct differentiated cell type present in mammary gland each with a distinct phenotype, a distinct epigenotype as well as distinct miRNA expression pattern. The aim of the study was to determine how epigen...
ORGANISM(S): Homo sapiens 
2011-04-05 | E-GEOD-28375 | biostudies-arrayexpress
TranscriptomicsGlobal gene transcription analysis of Anaplasma phagocytophilum in tick and human cells using tiling microarrays
A whole genome tiling microarray based on the published sequence of the Anaplasma phagocytophilum (Ap) strain Hz genome was used to measure transcriptional activity of Ap grown to late stage in three cell lines representing the diversity of host cells naturally infected by Ap: two human cell lines, ...
ORGANISM(S): Anaplasma phagocytophilum HZ 
2008-08-04 | E-GEOD-11487 | biostudies-arrayexpress
TranscriptomicsGene array of human mammary epithelial cell HMEC transfected with miR-106a-3p mimic against transfected control mimic
Since a single miRNA can potentially target hundreds of genes. In parallel, to study the effect of the over-expression of miR-106a-3p on global gene expression patterns, we isolated total RNA from HMEC cells transfected with miR-106a-3p mimic and performed microarray analysis (HG-U133 Plus 2.0).
ORGANISM(S): Homo sapiens 
2018-03-28 | E-MTAB-6594 | biostudies-arrayexpress
TranscriptomicsmiRNA genes in HMEC and HMF
This SuperSeries is composed of the following subset Series: GSE28374: DNA methylation of miRNA genes in HMEC and HMF GSE28375: Histone H3 acetylation of miRNA genes in HMEC and HMF GSE28376: Histone H3 lysine 27 trimethylation of miRNA genes in HMEC and HMF GSE28377: Histone H3 lysine 4 trimethylat...
ORGANISM(S): Homo sapiens 
2011-04-05 | E-GEOD-28380 | biostudies-arrayexpress
GenomicsEffect of the exosomes from cardiopulmonary progenitors on gene expression of HMEC-1 cells
Effect of the exosomes from cardiopulmonary progenitors on gene expression of HMEC-1 cells
PRJNA973121 | ENA
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