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TranscriptomicsHMGA1: A master regulator of tumor progression in triple-negative breast cancer cells
Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process are poorly understood. Here, we show for the first time that the high mobility group A1 (HMGA1) gene drives metastatic progression in triple ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-45483 | biostudies-arrayexpress
TranscriptomicsPivotal role of HMGA1 gene signature in highly metastatic breast cancer
Analysis of MDA-MB-231 breast cancer cells depleted for High Mobility Group A1 (HMGA1) using siRNA. HMGA1 is involved in invasion and metastasis in breast cancer cells. Results identify the specific transcriptional program induced by HMGA1 in highly metastatic breast cancer cells. MDA-MB-231 cells w...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-35525 | biostudies-arrayexpress
ProteomicsProteomic analysis of HMGA1-silencing
HMGA1 is a well-established oncogene and is a master regulator in breast cancer cells controlling the shift from a non-tumorigenic epithelial-like phenotype towards a highly aggressive mesenchymal-like one. In this work we compared HMGA1-silenced versus control MDA-MB-231 by means of a label free sh...
ORGANISM(S): Homo sapiens (Human) 
2018-10-17 | PXD002032 | Pride
Label free proteomics High mobility protein hmga1 Filter aided sample preparation Breast cancer 
ProteomicsPhosphopattern Predicts CK2 Substrate, HMGA1, as a Drug Resistant Target for Non-Small Cell Lung Cancer
Lung adenocarcinoma cells harboring epidermal growth factor receptor (EGFR) mutations are sensitive to EGFR tyrosine kinase inhibitors (TKIs), including gefitinib. Acquired resistance to EGFR-TKIs develops after prolonged treatments. Known mechanisms for EGFR-TKI resistance, including KRAS mutation,...
ORGANISM(S): Homo sapiens (Human) 
2018-05-08 | PXD000861 | Pride
Imac Phosphoproteome Hmga1 Drug resistance Ck2 Lung cancer 
GenomicsHMGA1 Chromatin Regulators Drive MPN Progression [ChIP-Seq]
HMGA1 Chromatin Regulators Drive MPN Progression [ChIP-Seq]
PRJNA783621 | ENA
GenomicsHMGA1 Chromatin Regulators Drive MPN Progression [scRNA-Seq]
HMGA1 Chromatin Regulators Drive MPN Progression [scRNA-Seq]
PRJNA812907 | ENA
GenomicsHMGA1 Chromatin Regulators Drive MPN Progression [ATAC-Seq]
HMGA1 Chromatin Regulators Drive MPN Progression [ATAC-Seq]
PRJNA783622 | ENA
GenomicsHMGA1 Chromatin Regulators Drive MPN Progression [RNA-Seq]
HMGA1 Chromatin Regulators Drive MPN Progression [RNA-Seq]
PRJNA760443 | ENA
GenomicsHMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation
HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation
PRJNA923709 | ENA
GenomicsHMGA1 promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis
HMGA1 promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis
PRJNA1040882 | ENA
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