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ProteomicsHMGN5, an RNA and Nucleosome binding protein required for chromatin de-condensation and gene activation
The packaging of DNA into chromatin and its compaction within cells renders the underlying DNA template un-accessible for processes like transcription, replication and repair. Active mechanisms as chromatin modifying activities or the association with non-coding RNAs can de-condense chromatin, rende...
ORGANISM(S): Homo sapiens (Human) 
2026-09-22 | PXD024386 | Pride
Lc-msms Hmgn5 Human Co-ip 
TranscriptomicsChromatin de-compaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.
In most metazoan nuclei, heterochromatin is located at the nuclear periphery in contact with the nuclear lamina, which provides mechanical stability to the nucleus. We show that in cultured cells, chromatin de-compaction by the nucleosome binding protein HMGN5 decreases the sturdiness, elasticity, a...
ORGANISM(S): Mus musculus 
2014-11-22 | E-GEOD-63530 | biostudies-arrayexpress
GenomicsHMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancer
HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancer
PRJNA796499 | ENA
UnknownHmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice.
Not available
S-EPMC5053560 | biostudies-literature
ProteomicsGrowth cone localization of the mRNA encoding a chromatin regulator modulates neurite outgrowth
Neurons exploit local mRNA translation and retrograde transport of transcription factors to regulate gene expression in response to signaling events at distal neuronal ends. Whether epigenetic factors could also be involved in such regulation is not known. We report that the mRNA encoding the HMGN5 ...
ORGANISM(S): Mus musculus (Mouse) 
2015-04-17 | PXD001070 | Pride
Hmgn5 Neuronal development Chromatin regulation 
UnknownMetabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism.
Not available
S-EPMC3879345 | biostudies-literature
GenomicsHMGN5, an RNA and Nucleosome binding protein required for chromatin de-condensation and gene activation [RNA-seq]
HMGN5, an RNA and Nucleosome binding protein required for chromatin de-condensation and gene activation [RNA-seq]
PRJNA699256 | ENA
GenomicsHMGN5, an RNA and Nucleosome binding protein required for chromatin de-condensation and gene activation [CLIP-seq]
HMGN5, an RNA and Nucleosome binding protein required for chromatin de-condensation and gene activation [CLIP-seq]
PRJNA699269 | ENA
GenomicsHMGN5, an RNA and Nucleosome binding protein required for chromatin de-condensation and gene activation [ChIP-seq]
HMGN5, an RNA and Nucleosome binding protein required for chromatin de-condensation and gene activation [ChIP-seq]
PRJNA699260 | ENA
UnknownDistinct properties of human HMGN5 reveal a rapidly evolving but functionally conserved nucleosome binding protein.
Not available
S-EPMC3133374 | biostudies-literature
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