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TranscriptomicsLong Noncoding RNA HNF1A-AS1 Regulates Proliferation and Migration in Esophageal Adenocarcinoma Cells
Objectives: Long non-coding RNAs (lncRNAs) have been shown to play important roles in the development and progression of cancer. However, functional lncRNAs and their downstream mechanisms are largely unknown in the molecular pathogenesis of esophageal adenocarcinoma (EAC) and its progression. Desig...
ORGANISM(S): Homo sapiens 
2013-10-21 | E-GEOD-48240 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse Hnf1a-deficient and wild-typehepatocytes with anti-Histone H3 dimethyl K4 -H3K4me2- antibody
Chromatin from Hnf1a-/- and wild-type mouse hepatocytes was immunoprecipitated with antibodies anti-H3K4me2 (Upstate 07-030). Amplified and labelled ChIP DNA and input DNA were hybridyzed to Mouse PromoterChip 5A.0 arrays.
ORGANISM(S): Mus musculus 
2009-03-21 | E-MEXP-1715 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from Hnf1a-deficient and wild type mice
RNA was extracted from Hnf1a/Tcf1 (Hepatocyte Nuclear Factor 1 alpha) knockout and wild-type mouse liver fractions. Gene expression profiles were compared using Affymetrix GeneChip Mouse Genome 430 2.0 arrays [Mouse430_2].
ORGANISM(S): Mus musculus 
2009-03-21 | E-MEXP-1709 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MIN6 cells overexpressing Hnf1a through CRISPR activation
To determine the impact of Hnf1a overexpression on gene expression in mouse beta cells, we performed RNA-seq experiments on MIN6 where Hnf1a was overexpressed using CRISPR activation (SAM system).
ORGANISM(S): Mus musculus 
2022-05-01 | E-MTAB-11474 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreatic islets from Hnf1a-deficient and wild type mice
Pancreatic islets were isolated from Hnf1a (Hepatocyte nuclear factor 1 alpha) knockout and wild-type mice and cultured ex vivo for two days in RPMI medium with 10% FBS before RNA extraction. The transcription profiles were obtained using Affymetrix GeneChip Mouse Genome 430A 2.0 arrays [Mouse430A_2...
ORGANISM(S): Mus musculus 
2009-03-21 | E-MEXP-1707 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pancreatic islets from heterozygous Hnf1a-mutant and wild type mice
Pancreatic islets were isolated from Hnf1a+/- (Hepatocyte nuclear factor 1 alpha) and wild-type mice and cultured ex vivo for two days in RPMI medium with 10% FBS before RNA extraction. The transcription profiles were obtained using Affymetrix GeneChip Mouse Genome 430 2.0 arrays [Mouse430_2].
ORGANISM(S): Mus musculus 
2009-03-21 | E-MEXP-1979 | biostudies-arrayexpress
GenomicsHNF1A, UTX, H3K27me3 and H3K27ac ChIP-seq in wild-type and UTX- or HNF1A-deficient mouse pancreas
HNF1A, UTX, H3K27me3 and H3K27ac ChIP-seq in wild-type and UTX- or HNF1A-deficient mouse pancreas
PRJEB32478 | ENA
GenomicsHNF1A, UTX, H3K27me3 and H3K27ac ChIP-seq in wild-type and UTX- or HNF1A-deficient mouse pancreas
HNF1A and UTX are putative tumor suppressors in pancreatic cancer. In this study, we have combined mouse genetics, transcriptomics and genome binding studies to link HNF1A and UTX in a molecular mechanism that suppresses pancreatic cancer. In this session, we have profiled UTX, HNF1A, H3K27me3 and H...
ORGANISM(S): Mus musculus 
2019-12-20 | E-MTAB-7944 | biostudies-arrayexpress
ProteomicsChanges in the proteome of human induced pluripotent stem cells derived endothelial cells with CRISPR/Cas9 induced monoallelic and biallelic mutation of the HNF1A gene
Maturity onset diabetes of the young (MODY) is caused by a mutation in a single gene and leads to diabetes under the age of 25. The mutations in HNF1A gene (leading to HNF1A-MODY) cause about 70% of all MODY cases. It was shown that patients with HNF1A-MODY often develop diabetic microvascular compl...
ORGANISM(S): Homo sapiens (Human) 
2026-03-01 | PXD039471 | Pride
Maturity onset diabetes of the young Endothelial cells Hnf1a-mody Ipscs-ec 
GenomicsEffect of HNF1A-MODY on stem cell islets
Effect of HNF1A-MODY on stem cell islets
PRJNA1375534 | ENA
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