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TranscriptomicsInduced-pluripotent stem-derived vascular endothelial cells in Down syndrome
To investigate the physiological characteristics of endothelial cells (EC) harboring trisomy 21 (T21), we establised isogenic pairs of T21-iPSCs and corrected disomy 21 (cDi21)-iPSCs We then performed gene expression profiling analysis using data obtained from RNA-seq of 5 different iPSC-derived ECs...
ORGANISM(S): Homo sapiens 
2022-05-20 | GSE203257 | GEO
UnknownEffects of cellular origin on differentiation of human induced pluripotent stem cell-derived endothelial cells.
Not available
S-EPMC4937999 | biostudies-literature
UnknownQuaking Is a Key Regulator of Endothelial Cell Differentiation, Neovascularization, and Angiogenesis.
Not available
S-EPMC5396345 | biostudies-literature
TranscriptomicsVascular niche induction of hematopoietic progenitors from pluripotent stem cells
Pluripotent stem cells (PSC) represent an alternative source of hematopoietic stem cells (HSCs). Clinical translation is impeded by limited engraftment of human (h)PSC-multipotent progenitor cells (MPP). This barrier suggests that additional cues are required for definitive hematopoiesis. We hypothe...
ORGANISM(S): Macaca nemestrina 
2015-12-31 | E-GEOD-64644 | biostudies-arrayexpress
TranscriptomicsHuman pluripotent stem cell derived hematopoietic cells using expanded potential stem cell media
We recently developed a novel chemical media formulation, Expanded Potential Stem Cell Medium (EPSCM), that maintains mouse pluripotent stem cells (PSCs) in a unique cellular state that affords extraembryonic differentiation capacity. Here, we have used EPSCM to stably maintain human PSCs and used E...
ORGANISM(S): Homo sapiens 
2022-04-26 | GSE130662 | GEO
ProteomicsProteomics of novel iPSC-derived vascular endothelial cells reveal extensive similarity with an immortalized human endothelial cell line
The vascular endothelium constitutes the inner lining of the blood vessel and is directly involved in the control of blood fluidity, vascular tone, platelet aggregation, regulation of immunity, inflammation, and angiogenesis. Malfunction and injuries of the endothelium can cause cardiovascular disea...
ORGANISM(S): Homo sapiens (Human) 
2023-07-05 | PXD038493 | Pride
Methylation Acetylation Endothelial cells Ipsc Phosphorylation 
UnknownGeneration of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells.
Not available
S-EPMC8812039 | biostudies-literature
UnknownDerivation and Characterization of Endothelial Cells from Porcine Induced Pluripotent Stem Cells.
Not available
S-EPMC9266935 | biostudies-literature
TranscriptomicsEndothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of Port Wine Birthmark
Background:Port wine birthmark (PWB) is a congenital vascular malformation resulting from developmentally defective endothelial cells (ECs). Developing clinically relevant disease models for PWB studies is currently an unmet need. Objective: Our study aims to generate PWB-derived induced pluripotent...
ORGANISM(S): Homo sapiens 
2023-09-14 | GSE240770 | GEO
TranscriptomicsPathophysiology of androgen-associated endothelial cell dysfunction in phenotype A polycystic ovarian syndrome revealed by iPSCs modeling
Abundant evidence suggests that women with polycystic ovary syndrome (PCOS) have increased metabolic aberrations and cardiovascular risks and present with signs of endothelial cell (EC) dysfunction. However, whether and how androgen is involved in the pathogenesis of EC dysfunction in PCOS remains u...
ORGANISM(S): Homo sapiens 
2023-11-01 | GSE246456 | GEO
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