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ProteomicsSEPN1-related myopathy depends on the oxidoreductase ERO1 alpha and is druggable with the chemical chaperone TUDCA
SEPN1-related myopathy depends on the oxidoreductase ERO1 alpha and is druggable with the chemical chaperone TUDCA
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD047157 | Pride
Tudca Multi mini-core disease Er stress Ero1 Sepn1 Core myopathy 
UnknownEarly induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models
Not available
S-SCDT-10_1038-S44321-024-00055-9 | biostudies-other
TranscriptomicsEarly postmortem gene expression and its relationship to composition and quality traits in pig Longissimus dorsi muscle
A mRNA expression study has been performed 20-25 minutes postmortem obtained samples from Longissimus dorsi muscle of 59 Duroc x LD/LW pigs to search for gene sequences related to meat quality (pH24, pH45, “Lab” colour coordinates, curing yield and exudation at three different times) or to meat com...
ORGANISM(S): Sus scrofa 
2011-09-19 | E-GEOD-32179 | biostudies-arrayexpress
TranscriptomicsGene Regulatory Circuitry of JNK Signaling Identifies Novel Regulators of Epithelial to Mesenchymal Transition
Purpose: The purpose of this study is to investigate role of JNK signaling during EMT. Method: Transcriptome of TGF-b treated NmuMG cells along with DMSO and JNKi treated NMuMG was generated using next generation high throughput sequencing in triplicates and duplicates respectively. Reads were mappe...
ORGANISM(S): Mus musculus 
2015-07-13 | E-GEOD-54133 | biostudies-arrayexpress
GenomicsUK_RCC_GWAS
Renal cell carcinoma (RCC) cases comprised adult patients with histologically proven RCC were collected through two sources within the UK. First, 856 cases from SORCE, a MRC collection of surgically treated RCC cases ascertained through UK clinical oncology centres. Second, 189 RCC cases collected t...
EGAD00010002310 | EGA
GenomicsUK renal cancer samples genotyped on Illumina OmniExpress BeadChip
Renal cell carcinoma (RCC) cases comprised adult patients with histologically proven RCC were collected through two sources within the UK. First, 856 cases from SORCE, a MRC collection of surgically treated RCC cases ascertained through UK clinical oncology centres. Second, 189 RCC cases collected t...
EGAS00001002336 | EGA
TranscriptomicsTranscription profiling of striatum from 12 weeks-old R6/2 mice and control mice (set 2)
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9804 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse striatum from 12 weeks-old R6/2 mice and control mice (set 1)
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic m...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9803 | biostudies-arrayexpress
GenomicsUK RCC DAC
Data Access Committee EGAC00001002629
EGAC00001002629 | EGA
TranscriptomicsOmega-3 fatty acids partially revert the metabolic gene expression profile induced by long-term calorie restriction
Calorie restriction (CR) consistently extends longevity and delays age-related diseases across several animal models. We have previously shown that different dietary fat sources can modulate life span and mitochondrial ultrastructure, function and membrane fatty acid composition in mice maintained o...
ORGANISM(S): Mus musculus 
2015-08-10 | E-GEOD-71773 | biostudies-arrayexpress
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