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Local catabolism of the amino acid tryptophan (Trp) by indoleamine-2,3-dioxygenase (IDO) is considered an important mechanism of regulating T cell immunity. We show that IDO transcription was increased upon stimulation of myelin-specific T cells with tolerogenic altered self-peptides. Catabolites of...
ORGANISM(S): Mus musculus 
HBPP_MultipleSclerosis_Phospho
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005154 | PeptideAtlas
HBPP_NormalControl_Phospho
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005150 | PeptideAtlas
Synovial antigen arrays were probed with 1:150 dilutions of plasma derived from SJL mice immunized with fibrinogen emulsified in CFA or with CFA alone. Autoantibody binding was detected with a Cy3-conjugated goat-anti-mouse IgG/M secondary antibody. SAM was applied to identify antigens with statis...
ORGANISM(S): Mus musculus 
A functionally diverse subset of yeast temperatures sensitive deletion mutants were transformed with a pool of barcoded yeast ORFs to identify dosage suppressors. Objective: To assess the relative strain proportion after growing DNA barcoded yeast deletion strains in a mixed pools. The barcodes are...
ORGANISM(S): Saccharomyces cerevisiae 
Plasma collected from mice with FIA were pooled, and 0.3 ml was injected intravenously into 6-week-old naïve SJL mice on days 0 and 2. Synovial antigen array profiling of plasma from the arthritic recipient mice demonstrated autoreactive B-cell responses against peptides representing native fibrino...
ORGANISM(S): Mus musculus 
Splenocytes harvested from mice with FIA were cultured in vitro and stimulated with 0.01 mg/ml fibrinogen for 3 days. Enriched T cells were transferred into 6-week-old naïve SJL mice, which developed visible signs of arthritis within 2 weeks. Synovial array profiling of plasma from the arthritic ...
ORGANISM(S): Mus musculus 
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