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GenomicsesBAF is an essential component of the core pluripotency transcriptional network
Distinctive SWI/SNF-like ATP-dependent chromatin remodeling esBAF complexes are indispensable for the maintenance and pluripotency of mouse embryonic stem (ES) cells. To understand the mechanism underlying the roles of these complexes in ES cells, we performed high-resolution genome-wide mapping of ...
ORGANISM(S): Mus musculus 
2009-01-20 | E-GEOD-14344 | biostudies-arrayexpress
ProteomicsDifferential complexome profiling of CRISTA WT and KO HEK293T mitochondria
CRISTA (SMIM26) is a mitochondrial microprotein important for assembly of complex I. Here we used differential complexome profiling to study the composition of ETC complexes in SMIM26 WT and KO HEK293T mitochondria. CRISTA potentiates mitochondrial serine import via direct interactions with the seri...
ORGANISM(S): Homo sapiens (Human) 
2025-06-18 | PXD047664 | Pride
Microproteins Complexome profiling Complex i Mitochondria Supercomplexes 
TranscriptomicsELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal Via the PI3K/AKT Pathway
ELABELA (ELA) is a peptide hormone required for heart development that signals via the Apelin Receptor (APLNR, APJ). ELA is also abundantly secreted by human embryonic stem cells (hESCs), which do not express APLNR. Here we show that ELA signals in a paracrine fashion in hESCs to maintain self-rene...
ORGANISM(S): Homo sapiens 
2015-09-20 | E-GEOD-71949 | biostudies-arrayexpress
TranscriptomicsChromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways
The SMC protein complexes safeguard genomic integrity through their functions in chromosome segregation and repair. The chromosomal localization of the budding yeast Smc5/6 complex here determined reveals that the complex works specifically on the duplicated genome in differently regulated pathways....
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4808 | biostudies-arrayexpress
UnknownCoding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity.
Not available
S-EPMC8035321 | biostudies-literature
TranscriptomicsInactivation of the Budding Yeast Cohesin Loader Scc2 alters Gene Expression both Globally and in Response to a Single DNA Double Strand Break
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2014-10-21 | E-GEOD-62494 | biostudies-arrayexpress
TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
GenomicsInactivation of the Budding Yeast Cohesin Loader Scc2 alters Gene Expression both Globally and in Response to a Single DNA Double Strand Break [ChIP-seq]
Genome integrity is fundamental for cell survival and cell cycle progression. Important mechanisms for keeping the genome intact are proper sister chromatid segregation, correct gene regulation and efficient repair of damaged DNA. Cohesin and its DNA loader, the Scc2/4 complex have been implicated i...
ORGANISM(S): Saccharomyces cerevisiae 
2014-10-21 | E-GEOD-62493 | biostudies-arrayexpress
UnknownMitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.
Not available
S-EPMC7066179 | biostudies-literature
TranscriptomicsesBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signaling and by regulating Polycomb function
Signaling by the cytokine LIF and its downstream transcription factor, STAT3, prevents differentiation of pluripotent embryonic stem cells (ESCs) by opposing MAP kinase signaling. This contrasts with most cell types where STAT3 signaling induces differentiation. We find that STAT3 binding across t...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-27708 | biostudies-arrayexpress
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