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ProteomicsThe CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
The cell-autonomous balance of immune-inhibitory and -stimulatory signals is a critical process in cancer immune evasion. Using patient-derived co-cultures, humanized mouse models, and single cell RNA-sequencing of patient melanomas biopsied before and on immune checkpoint blockade, we find that int...
ORGANISM(S): Homo sapiens (Human) 
2023-07-06 | PXD039710 | Pride
Human Cd58 Melanoma 
GenomicsNational Cancer Institute Genome-Wide Association Study of Renal Cell Carcinoma

The National Cancer Institute (NCI) genome-wide association study (GWAS) of renal cell carcinoma (RCC) was conducted to investigate common genetic variants associated with RCC risk. The GWAS includes 1,453 RCC cases and 3,531 controls of European background from 4 studies (3 cohort, 1 case-con...

phs000351.v1.p1 | EGA
TranscriptomicsProtection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling
Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF-beta/Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3 deficient mice are protected from diet-induced obesity and...
ORGANISM(S): Mus musculus 
2011-07-12 | E-GEOD-28598 | biostudies-arrayexpress
TranscriptomicsPTHR1 knock-down in osteosarcoma cells
Expression analysis of OS tumors with shRNA knockdown of PTHR1 mouse OS 80 (a Cre:lox OS cell line from Boston) was tagged with firefly luciferase expression construct. They were then infected with either control (renilla luciferase shRNA) or an shRNA that effective knocks-down PTHR1 (PTHR1.358; par...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-46861 | biostudies-arrayexpress
UnknownSystematic Review of Prevalence of Young Child Overweight and Obesity in the United States-Affiliated Pacific Region Compared With the 48 Contiguous States: The Children's Healthy Living Program.
Not available
S-EPMC4265894 | biostudies-literature
TranscriptomicsMolecular Signatures of Fetal and Adult Prostate Stem Cells
The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. A distinctive core of transcriptional regulators common to both fetal and adult primit...
ORGANISM(S): Mus musculus 
2009-04-29 | E-GEOD-15580 | biostudies-arrayexpress
TranscriptomicsProfiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas
Human uterine leiomyomas (ULM) are characterized by dysregulation of a large number of genes and non-coding regulatory microRNAs. In order to identify microRNA::mRNA associations relevant to ULM pathogenesis, we examined global correlation patterns between the altered microRNA expression and the pre...
ORGANISM(S): Homo sapiens 
2010-07-24 | E-GEOD-23112 | biostudies-arrayexpress
Genomicsena-DATASET-BTRC-03-04-2014-18:00:02:250-43 - samples
Whole genome alignments of DIPG patients
EGAD00001000814 | EGA
Genomicsena-DATASET-BTRC-26-04-2017-20:29:35:774-41 - samples
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment. To understand what drives DIPGs we integrated whole-genome-sequencing with methylation, expression and copy-number profiling.
EGAD00001003305 | EGA
GenomicsWhole genome sequencing and whole exome sequencing of DIPG tumors and matched normal tissue
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment. To understand what drives DIPGs we integrated whole-genome-sequencing with methylation, expression and copy-number profiling.
EGAS00001000575 | EGA
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